Evidence map›Paper›PMID 40460399›Full record

ArticleAmerican journal of speech-language pathology2025

Construct Validity of the Amyotrophic Lateral Sclerosis Bulbar Dysfunction Index-Remote.

Timothy Pommée, Liziane Bouvier, Carolina Barnett-Tapia, Marc F Maffei, Sarah E Gutz, Victoria E Tilton-Bolowsky, Rosemary Martino, James D Berry, Agessandro Abrahao, Lorne Zinman and 2 more

Abstract readValidation StudyMulticenter Study
In one paragraph

Article in American journal of speech-language pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Timothy PomméeHurvitz Brain Sciences Research Program, Sunnybrook Research Institute, Toronto, Ontario, Canada.ORCID 0000-0001-7846-7282
Liziane BouvierHurvitz Brain Sciences Research Program, Sunnybrook Research Institute, Toronto, Ontario, Canada.ORCID 0000-0002-7239-7639
Carolina Barnett-TapiaDivision of Neurology, Department of Medicine, University of Toronto and University Health Network, Ontario, Canada.ORCID 0000-0001-5546-0221
Marc F MaffeiSargent College of Health & Rehabilitation Sciences, Boston University, MA.ORCID 0000-0001-6341-1702
Sarah E GutzDepartment of Communication Sciences and Disorders, MGH Institute of Health Professions, Boston, MA.ORCID 0000-0002-1601-0639
Victoria E Tilton-BolowskyDepartment of Communication Sciences and Disorders, MGH Institute of Health Professions, Boston, MA.
Rosemary MartinoDepartment of Speech-Language Pathology, Rehabilitation Sciences Institute, University of Toronto, Ontario, Canada.
James D BerryDepartment of Neurology, Harvard Medical School, Massachusetts General Hospital, Boston.
Agessandro AbrahaoHurvitz Brain Sciences Research Program, Sunnybrook Research Institute, Toronto, Ontario, Canada.ORCID 0000-0003-1142-2842
Lorne ZinmanHurvitz Brain Sciences Research Program, Sunnybrook Research Institute, Toronto, Ontario, Canada.ORCID 0000-0002-8096-8366
Jordan R GreenDepartment of Communication Sciences and Disorders, MGH Institute of Health Professions, Boston, MA.ORCID 0000-0002-1464-1373
Yana YunusovaHurvitz Brain Sciences Research Program, Sunnybrook Research Institute, Toronto, Ontario, Canada.ORCID 0000-0002-2353-2275

Funding

Advanced Research Training in Communication Sciences and DisordersT32DC013017 · NIDCD · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI Cara E. Stepp · 2016 to 2026
$4.9M
The development and validation of a novel tool for the assessment of bulbar dysfunction in ALSR01DC017291 · NIDCD · SUNNYBROOK RESEARCH INSTITUTE · PI JORDAN R GREEN, Yana Yunusova · 2018 to 2026
$3.6M
Kinematic and Acoustic Analysis of Speech in Autism Spectrum DisorderF31DC020108 · NIDCD · MGH INSTITUTE OF HEALTH PROFESSIONS · PI MAFFEI, MARC · 2021 to 2023
$104k
NIDCD NIH HHS F31 DC020108NIDCD NIH HHS R01 DC017291NIDCD NIH HHS T32 DC013017
6 · The paper itself

Abstract

purposeThe Amyotrophic Lateral Sclerosis Bulbar Dysfunction Index-Remote (ALSBDI-R) is a clinician-administered tool designed to assess bulbar dysfunction remotely in patients with amyotrophic lateral sclerosis (ALS). This study aimed to evaluate the construct validity of the ALSBDI-R by examining its correlation with established clinical measures and its ability to discriminate among different bulbar disease severities.

methodA total of 92 patients with ALS were recruited from two multidisciplinary clinics. Participants were assessed using the ALSBDI-R, the Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-R), the Center for Neurologic Study Bulbar Function Scale (CNS-BFS), the Sentence Intelligibility Test, and the Eating Assessment Tool (EAT-10). Construct validity was established through Spearman correlations and comparison of ALSBDI-R scores across bulbar severity groups (asymptomatic, mild, moderate, severe).

resultsStrong correlations were found between ALSBDI-R total scores and bulbar-specific measures such as ALSFRS-R bulbar subscore (

conclusionsThe ALSBDI-R is a valid tool for remotely assessing bulbar dysfunction in patients with ALS. Despite several limitations, its ability to capture varying degrees of severity makes it valuable for clinical use and research, offering a standardized approach to monitor disease progression remotely.

Indexed as

Amyotrophic Lateral SclerosisAdultAgedDisability EvaluationFemaleHumansMaleMiddle AgedPredictive Value of TestsReproducibility of ResultsSeverity of Illness IndexSpeech Intelligibility

Identifiers

PMID40460399
PMCPMC12270837

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.