ReviewAutonomic neuroscience : basic & clinical2025
Menopause and its effects on autonomic regulation of blood pressure: Insights and perspectives.
Review in Autonomic neuroscience : basic & clinical, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of heart rate variability and menopausal vasomotor symptoms.Physiological reports · 2026Pooled it
- Sex differences in blood pressure and hypertension through adulthood.Clinical kidney journal · 2026Article
- Associations Between Acute Heat Exposure and Hospitalization for Takotsubo Syndrome in the State of California, 2006 to 2019.Journal of the American Heart Association · 2026Article
- Postural Orthostatic Tachycardia Syndrome, Menopause and Hormone Replacement Therapy: Clinical Decisions in Times of Uncertainty.Journal of clinical medicine · 2026Review
- Female sex hormones do not drive the sex-specific mechanisms of obesity-related hypertension.American journal of physiology. Heart and circulatory physiology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Cardiovascular disease (CVD) risk increases substantially around the typical age of menopause (∼51 yrs). While the mechanisms underlying this phenomenon remain to be precisely elucidated, menopause-related autonomic (dys)function likely plays a key role in CVD development in postmenopausal females. Sympathetic activity is known to increase with age and may rise more steeply in older females, resulting in autonomic imbalance and chronic disease. The menopausal loss of estradiol, a major female sex hormone, contributes to changes in autonomic and vascular physiology and is implicated in prominent menopause symptoms such as sleep difficulty and vasomotor symptoms (hot flushes/night sweats). Estrogen replacement can mitigate some of these negative health effects, but hormone therapy may not be able to reverse all menopause-linked autonomic dysfunction. Thus, this review explores the vast and complex web connecting menopause physiology and symptomatology, including how sex-hormone loss and menopause symptoms may impact autonomic function- in particular, through altered sympathetic regulation of blood pressure and impaired vagal tone- as a gateway to adverse cardiovascular health and greater CVD risk.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.