Evidence map›Paper›PMID 40460908›Full record

ArticleContemporary clinical trials2025

Design of the SHARE study: A randomized controlled trial evaluating the regulation of cues treatment for adults with overweight or obesity and high food responsiveness.

Kerri N Boutelle, Dawn M Eichen, Saori Obayashi, Ellen K Pasquale, David R Strong, Allison S Tietz, Kristie L Reed, Carol B Peterson

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Contemporary clinical trials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05004883 (Targeting Food Cue Responsiveness for Weight Loss), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05004883 naactive not recruitingnot on this map

Targeting Food Cue Responsiveness for Weight Loss

TypeinterventionalSponsorUniversity of California, San DiegoRan2021 to 2026Enrolled300ConditionsOverweight and ObesityArmsRegulation of Cues Enhanced, Behavioral Weight Loss, Nutrition Education, Stress Management and Social Support
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kerri N BoutelleDepartment of Pediatrics, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA; Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA; Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA. Electronic address: kboutelle@health.ucsd.edu.
Dawn M EichenDepartment of Pediatrics, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Saori ObayashiDepartment of Pediatrics, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Ellen K PasqualeDepartment of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA; San Diego State University/University of California San Diego Joint Doctoral Program in Clinical Psychology, 6363 Alvarado Court, Suite 102, San Diego, CA 92120, USA.
David R StrongHerbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Allison S TietzDepartment of Pediatrics, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Kristie L ReedDepartment of Pediatrics, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Carol B PetersonDepartment of Psychiatry and Behavioral Sciences, University of Minnesota, F282/2A West 2450 Riverside Ave, Minneapolis, MN 55454, USA.

Funding

UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3M
Targeting food cue responsiveness for weight lossR01DK122504 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BOUTELLE, KERRI N · 2020 to 2024
$3.4M
NCATS NIH HHS UL1 TR001442NIDDK NIH HHS R01 DK122504
6 · The paper itself

Abstract

Obesity is a heterogeneous disease influenced by individual behavioral factors, environment, genes, and neural processes. Behavioral weight loss (BWL), the current gold-standard treatment for overweight and obesity (OW/OB), does not produce sustained weight loss for all individuals. Appetitive traits, such as food responsiveness (FR), are risk factors that could account for differences in how individuals interact with today's food environment and increase susceptibility for overeating and weight gain. Research shows that individuals high in FR have attenuated weight loss in BWL programs. We developed the Regulation of Cues (ROC) program to reduce overeating through improving sensitivity to hunger and satiety cues and decreasing FR. In this study, we combined ROC with BWL recommendations (ROC+BWL), a treatment approach that may address the unique needs of this phenotype. The current study is a 3-arm randomized controlled trial comparing the ROC+BWL program to BWL and an active comparator on body mass index. Two hundred ninety-three adults with high FR and OW/OB were randomized to 1 of 3 treatment arms and will complete 6 months of treatment and assessment visits over 18 months: baseline, during treatment, post-treatment (6 months), 6-month follow-up (12 months) and 12-month follow-up (18 months). This study could provide important evidence regarding the ROC+BWL program among individuals with high FR and OW/OB and may inform future precision medicine approaches for OW/OB. Clinical trials # NCT05004883.

Indexed as

Behavior TherapyCuesHyperphagiaObesityOverweightWeight Reduction ProgramsAdultBody Mass IndexFeeding BehaviorFemaleHumansHungerMaleMiddle AgedRandomized Controlled Trials as TopicWeight LossAppetitive traitsBehavioral weight lossFood responsivenessObesityRegulation of cuesSatiety responsivenessWeight loss

Identifiers

PMID40460908
PMCPMC12248186

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.