Evidence map›Paper›PMID 40461013›Full record

ArticleNeuro-oncology2025

TUXEDO-3: A phase 2 trial of patritumab deruxtecan for patients with leptomeningeal metastasis.

Emilie Le Rhun, Enrico Franceschi, Michael Weller

Abstract read
In one paragraph

Article in Neuro-oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Emilie Le RhunDepartment of Medical Oncology and Hematology, Brain Tumor Center, University Hospital and University of Zurich, Zurich, Switzerland.ORCID 0000-0002-9408-3278
Enrico FranceschiDepartment of Nervous System Medical Oncology, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.ORCID 0000-0001-9332-4677
Michael WellerDepartment of Neurology, Brain Tumor Center, University Hospital and University of Zurich, Zurich, Switzerland.ORCID 0000-0002-1748-174X

Funding

Promedica FoundationSophien FoundationStiftung für angewandte KrebsforschungUniversity Hospital Zurich Cancer Center
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID40461013
PMCPMC12448835

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.