SynthesisNutrition & diabetes2025
Dietary protein and risk of type 2 diabetes: findings from a registry-based cohort study and a meta-analysis of prospective cohort studies.
Synthesis in Nutrition & diabetes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed, 1 synthesis or guideline pooled it.
- High-protein diets and metabolic dysfunction-associated steatotic liver disease: A double-edged sword in liver health.World journal of gastroenterology · 2026Pooled it
- The association between dietary carbohydrate to protein ratio and risk of cardiovascular disease, type 2 diabetes, and metabolic syndrome in Iranian adults: a cohort study.Journal of health, population, and nutrition · 2026Article
- Long-term high-protein diet intake accelerates adipocyte senescence through macrophage CD38-mediated NADMolecular metabolism · 2026Article
- China precision nutrition biobank: protocol of a prospective cohort study on diet, human phenotype/genotype, and early-onset chronic diseases.Nutrition journal · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesLifestyle intervention, especially dietary modification, has been the cornerstone in preventing type 2 diabetes (T2D). We aimed to investigate the associations of various protein intake exposures with the risk of incident T2D in adults with or without metabolic diseases.
methodsWe followed 29517 residents enrolled in the Shanghai Suburban Adult Cohort and Biobank (SSACB) without diabetes at baseline through the electronic information system. Cox proportional hazard models were used to evaluate the associations of various protein intake exposures with the risk of incident T2D, visualized by restricted cubic splines (RCS). Propensity-score matching and subgroup analysis were used to characterize the association between total protein and incident T2D by metabolic diseases. Meta-analysis further explored the association between protein intake and incident T2D in broader populations.
resultsIn SSACB, 1511 (5.1%) participants developed T2D during a median follow-up period of 5.69 years. A U-shaped association between total protein and risk of incident T2D was found (protective range: 12.20-16.85 percentage energy (%E), cut-off point: 14.53%E). The U-shaped association (P-nonlinear < 0.001) remained in adults with hypertension with a narrower protective range (12.20-15.35%E), with a linear association in adults with NAFLD (HR per 1%E: 0.952, 95% CI: [0.910, 0.995]), whereas no significant association in adults with hyperlipidemia or central obesity. A negative association between plant protein and risk of incident T2D was also found in SSACB (HR per 1%E: 0.947, 95% CI: [0.900, 0.996]). In addition, the U-shaped association of total protein with the risk of incident T2D was reaffirmed in the dose-response meta-analysis (cut-off point: 15.10%E).
conclusionIn SSACB, a U-shaped association between total protein intake and risk of incident T2D was found, which was reaffirmed in the dose-response meta-analysis, and differed by metabolic diseases, especially hypertension and NAFLD. Moreover, plant protein was inversely associated with the risk of incident T2D.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.