Evidence map›Paper›PMID 40461519›Full record

ArticleScientific reports2025

Exploring novel of 1,2,4-triazolo[4,3-a]quinoxaline sulfonamide regioisomers as anti-diabetic and anti-Alzheimer agents with in-silico molecular docking simulation.

Moustafa S Abusaif, Ahmed M Sh El-Sharief, Yehia A Mohamed, Yousry A Ammar, Mostafa A Ismail, Wael M Aboulthana, Mohamed S A El-Gaby, Ahmed Ragab

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Moustafa S AbusaifChemistry Department, Faculty of Science (boys), Al-Azhar University, Nasr City, 11884, Cairo, Egypt. mostafahozaifa317@azhar.edu.eg.ORCID https://orcid.org/0000-0002-1084-3904
Ahmed M Sh El-ShariefChemistry Department, Faculty of Science (boys), Al-Azhar University, Nasr City, 11884, Cairo, Egypt.
Yehia A MohamedChemistry Department, Faculty of Science (boys), Al-Azhar University, Nasr City, 11884, Cairo, Egypt.
Yousry A AmmarChemistry Department, Faculty of Science (boys), Al-Azhar University, Nasr City, 11884, Cairo, Egypt.
Mostafa A IsmailChemistry Department, Faculty of Science, Al-Azhar University, Assiut, 71524, Egypt.
Wael M AboulthanaBiochemistry Department, Biotechnology Research Institute, National Research Centre, 33 El Buhouth St., Dokki 12622, Cairo, Egypt.
Mohamed S A El-GabyChemistry Department, Faculty of Science (boys), Al-Azhar University, Nasr City, 11884, Cairo, Egypt. m_elgaby@azhar.edu.eg.ORCID https://orcid.org/0000-0002-4902-5546
Ahmed RagabChemistry Department, Faculty of Science (boys), Al-Azhar University, Nasr City, 11884, Cairo, Egypt. Ahmed_ragab@azhar.edu.eg.ORCID https://orcid.org/0000-0001-8542-7465

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, a novel series of 1,2,4-triazolo[4,3-a]quinoxalines containing a sulfonamide moiety was designed and synthesized through regioselective synthesis from 2 and/ 3-hydrazino-6-(pyrrolidin-1-ylsulfonyl)quinoxaline derivatives 5 and 7. The structures of two isomers were confirmed and characterized by IR,

Indexed as

Alzheimer DiseaseHypoglycemic AgentsQuinoxalinesSulfonamidesTriazolesAcetylcholinesterasealpha-Amylasesalpha-GlucosidasesCholinesterase InhibitorsGlycoside Hydrolase InhibitorsHumansMolecular Docking SimulationStructure-Activity RelationshipAcetylcholinesterasealpha-Amylasesalpha-GlucosidasesCholinesterase InhibitorsGlycoside Hydrolase InhibitorsHypoglycemic AgentsQuinoxalinesSulfonamidesTriazoles1,2,4-triazolo[4,3-a]quinoxalineAcetylcholinesterase inhibitorsMolecular docking simulationRegioselective synthesisΑ-amylase and α-glucosidase inhibitors

Identifiers

PMID40461519
PMCPMC12134304

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.