Evidence mapPaperPMID 40461547Full record

ArticleScientific reports2025

Mathematical analysis of modified blood glucose insulin model through fractal fractional operators.

F Gassem, Abrar Zahir, Arafa Dawood, Mohammed Almalahi, Amjad Ali, Khaled Aldwoah

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Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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6 authors.

F GassemDepartment of Mathematics, University of Ha'il, 55473, Ha'il, Saudi Arabia.
Abrar ZahirDepartment of Mathematics and Statistics, University of Swat, Khyber Pakhtunkhwa, Pakistan.
Arafa DawoodDepartment of Mathematics, College of Science, King Khalid University, P.O. Box 9004, Abha, 61413, Saudi Arabia.
Mohammed AlmalahiDepartment of Mathematics, College of Computer and Information Technology, Al-Razi University, 12544, Sana'a, Yemen. dralmalahi@gmail.com.
Amjad AliDepartment of Mathematics and Statistics, University of Swat, Khyber Pakhtunkhwa, Pakistan.
Khaled AldwoahDepartment of Mathematics, Faculty of Science, Islamic University of Medinah, 42351, Madinah, Saudi Arabia. aldwoah@iu.edu.sa.

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6 · The paper itself

Abstract

This study presents an advanced mathematical perspective of a generalized diabetes model, emphasizing the critical complications associated with this disease, such as cardiovascular disease, kidney failure, nerve damage, vision problems, and weakened immunity conditions, which can escalate into life-threatening conditions such as heart attacks, strokes, and blindness. Blood glucose, an essential energy source for the human body, is regulated by hormones such as insulin and glucagon. Diabetes emerges either due to the body's resistance to insulin or the autoimmune destruction of insulin-producing cells in the pancreas. Focusing on these physiological insights, we reformulate the blood glucose-insulin (MBGI) model by incorporating some novel parameters, introducing a dietary intake compartment, and employing a new fractional operator in the sense of a fractal-fractional derivative to better capture the complex dynamics of the disease. This study investigates the existence, uniqueness, and Hyers-Ulam stability of solutions via fixed-point approaches, particularly Leray-Schauder techniques. Furthermore, a numerical scheme based on Newton's polynomial interpolation is developed to visualize the behavior of the model. The attained results show that increasing both the fractal dimension and fractional order leads to a crucial reduction in glucose concentration, offering valuable insights for the effective management and control of diabetes.

Indexed as

Blood GlucoseDiabetes MellitusInsulinModels, BiologicalModels, TheoreticalFractalsHumansBlood GlucoseInsulinBergman Minimal ModelExistence TheoryFractal-Fractional OperatorNumerical AnalysisStability Analysis

Identifiers

PMID40461547
PMCPMC12134202

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