ArticleInternational journal of obesity (2005)2025
Association between adiposity distribution and high-sensitivity C-reactive protein, adipokines, interleukins and plasminogen activator inhibitor-1.
Article in International journal of obesity (2005), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- The Association Between Serum C-Reactive Protein Levels and Body Fat Parameters: Results from the Korean National Health and Nutrition Examination Survey.Medicina (Kaunas, Lithuania) · 2026Article
- Obesity is the culprit behind fatty acid-induced inflammation.Nutrition & metabolism · 2026Review
- Associations of Obesity, Inflammatory Indicators, and Serum Testosterone in Adult Males: A Cross-Sectional Study Based on NHANES 2011-2016 and 2021-2023.American journal of men's healthArticle
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectiveThe location of the adipose tissue within the human body is related with different inflammatory status, however there is still no plain understanding on which fat depots are associated with increasing or decreasing concentrations of specific markers of inflammation. This study aimed to estimate the associations between total body fat, limbs' fat and trunk fat with several markers of inflammation. SUBJECTS/
methodsA cross-sectional analysis of 546 adults (aged 27 years) was conducted as part of the EPITeen cohort. Variables on adiposity were assessed using whole-body dual-energy X-ray absorptiometry (DXA). Markers of inflammation were determined based on the serum concentrations of high-sensitivity C-reactive protein (hsCRP), adiponectin, leptin, resistin, interleukin (IL)-1β, IL-6, IL-8, IL-10, and plasminogen activator inhibitor-1 (PAI-1) of the participants. The associations were estimated by linear regression models - models based on ordinary least squares (OLS) and least absolute shrinkage and selection operator (LASSO) were performed.
resultsTrunk fat and limbs' fat have significantly different associations [β (95% CI)] with the same marker of inflammation. This applies to hsCRP in men [trunk: 0.065 (0.025, 0.106), limbs: -0.050 (-0.103, 0.004)], adiponectin in both sexes [trunk: -0.088 (-0.144, -0.032), limbs: 0.125 (0.054, 0.196) for women; trunk: -0.084 (-0.124, -0.044), limbs: 0.073 (0.020, 0.126) for men], leptin in women [trunk: 0.037 (0.003, 0.070), limbs: 0.116 (0.074, 0.159)], and PAI-1 in women [trunk: 0.025 (0.006, 0.044), limbs: -0.021 (-0.045, 0.003)].
conclusionsWe found significant differences between limbs' and trunk fat for hsCRP (men), adiponectin (both sexes), leptin (women), and PAI-1 (women), with trunk fat being associated with higher levels of pro-inflammatory markers.
Indexed as
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Registered trials
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