Evidence mapPaperPMID 40461967Full record

ReviewMolecular medicine (Cambridge, Mass.)2025

Exploring the role of palmitoylation in sepsis: mechanistic insights and future perspectives.

Susu Cao, Wenyan Xiao, Sinong Pan, Tianfeng Hua, Min Yang

Abstract readReview
In one paragraph

Review in Molecular medicine (Cambridge, Mass.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. ZDHHC5 may regulate the function of NKT cells and the immune response in Meniere's disease.Mammalian genome : official journal of the International Mammalian Genome Society · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Susu CaoThe Second Department of Critical Care Medicine, The Second Affiliated Hospital of Anhui Medical University, 678 Furong Road, Hefei, 230601, Anhui Province, China.
Wenyan XiaoThe Second Department of Critical Care Medicine, The Second Affiliated Hospital of Anhui Medical University, 678 Furong Road, Hefei, 230601, Anhui Province, China.
Sinong PanThe Second Department of Critical Care Medicine, The Second Affiliated Hospital of Anhui Medical University, 678 Furong Road, Hefei, 230601, Anhui Province, China.
Tianfeng HuaThe Second Department of Critical Care Medicine, The Second Affiliated Hospital of Anhui Medical University, 678 Furong Road, Hefei, 230601, Anhui Province, China.
Min YangThe Second Department of Critical Care Medicine, The Second Affiliated Hospital of Anhui Medical University, 678 Furong Road, Hefei, 230601, Anhui Province, China. yangmin@ahmu.edu.cn.

Funding

National Natural Science Foundation of China 8207213Research Fund of Anhui Institute of Translational Medicine 2023zhyx-C64 and 2022zhyx-C76
6 · The paper itself

Abstract

backgroundThe palmitoylation system is intricate, multidimensional, and plays a crucial role in various inflammatory and immune-related disorders. Palmitoylation controls protein stability, cargo sorting, signal transmission, as well as cell differentiation and death. Notably, a growing body of studies has highlighted its participation in inflammatory processes, either directly or indirectly, indicating its broad and complex involvement in the development of sepsis. Understanding the mechanisms underlying palmitoylation is essential for advancing research on sepsis. We began this review with a brief summary of research related to sepsis progression. Second, we went over recent studies on palmitoylation. Third, we compiled and described palmitoylation-related alterations in vital molecules or biological processes involved in sepsis. Lastly, we outlined the promising features of palmitoylation and proposed a hopeful outlook for future research in sepsis.

Indexed as

LipoylationSepsisAnimalsHumansProtein Processing, Post-TranslationalSignal TransductionImmunityPalmitoylationPathogenesisSepsis

Identifiers

PMID40461967
PMCPMC12131612

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.