Evidence map›Paper›PMID 40461990›Full record

ArticleBMC nephrology2025

Effects of RAAS blockade on acute kidney injury in head and neck cancer patients post-chemoradiotherapy.

Yi-Ting Chen, Yao-Hung Kuo, Chih-Feng Lin, Chun-Wei Wang, Chiao-Ling Tsai

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Article in BMC nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Yi-Ting ChenDivision of Nephrology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
Yao-Hung KuoDepartment of Radiation Oncology, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan.
Chih-Feng LinDepartment of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan.
Chun-Wei WangDivision of Radiation Oncology, Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan.
Chiao-Ling TsaiDivision of Radiation Oncology, Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan. eugeniatsai@ntu.edu.tw.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe incidence of acute kidney injury (AKI) is high among head and neck cancer (HNC) patients following Platinum-based concurrent chemo-radiotherapy (CCRT). However, the effect of renin-angiotensin-aldosterone system (RAAS) blockade on the risk of AKI in HNC patients undergoing CCRT is controversial. This study aimed to investigate the association between RAAS blockade, AKI and survival in HNC patients undergoing CCRT.

methodThis retrospective cohort study included 989 HNC patients treated between January 2016 and July 2022, with follow-up extending to July 2022. Among them, 65 (6.6%) patients were using RAAS blockade for hypertension control, while 924 were non-users. Clinical data and demographics were retrieved. Cox regression models were employed to analyze primary outcomes, including AKI and patient survival.

resultsThere were 65 (6.6%) patients being RAAS blockade users in the study. The mean age of RAAS blockade users was older than that of non-users (61 vs. 55 years old, p < 0.001). Overall, 219 (22.1%) patients developed AKI, including 25 RAAS blockade users. RAAS blockade users had a higher risk of AKI compared to non-users (38% vs. 21%, p = 0.001) and also had a worse mortality rate (35% vs. 22%, p = 0.015). Factors such as male gender, age, RAAS blockade usage, and baseline serum creatinine levels independently predicted the onset of AKI and patient survival.

conclusionRAAS blockade users developed AKI, which significantly predicted patient survival. Diligent post-CCRT renal function monitoring and hydration in RAAS blockade users are crucial to mitigate AKI risk and potentially improve survival in this patient group.

Indexed as

Acute Kidney InjuryAngiotensin-Converting Enzyme InhibitorsAngiotensin Receptor AntagonistsChemoradiotherapyHead and Neck NeoplasmsRenin-Angiotensin SystemAdultAgedFemaleHumansMaleMiddle AgedRetrospective StudiesAngiotensin-Converting Enzyme InhibitorsAngiotensin Receptor AntagonistsAcute kidney injuryHead and neck cancerRAAS blockade

Identifiers

PMID40461990
PMCPMC12135316

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.