Evidence map›Paper›PMID 40462659›Full record

ArticleBrain and behavior2025

⁠⁠Functional Foods Alleviate Behavioral Alterations and Improve GABAergic System Regulating TLR-4/NF-κB Axis in Valproic-Induced Autism.

Francesco Molinari, Roberta Fusco, Rosalba Siracusa, Ramona D'Amico, Daniela Impellizzeri, Ali S Abdelhameed, Tilman Fritsch, Ursula M Jacob, Salvatore Cuzzocrea, Vittorio Calabrese and 2 more

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In one paragraph

Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Francesco MolinariDepartment of Veterinary Sciences, University of Messina, Messina, Italy.
Roberta FuscoDepartment of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Messina, Italy.
Rosalba SiracusaDepartment of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Messina, Italy.
Ramona D'AmicoDepartment of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Messina, Italy.
Daniela ImpellizzeriDepartment of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Messina, Italy.
Ali S AbdelhameedDepartment of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Kingdom of Saudi Arabia.
Tilman FritschNAM-Institute, Salzburg, Austria.
Ursula M JacobSystem Biologie AG, Wollerau, Switzerland.
Salvatore CuzzocreaDepartment of Chemical, Biological, Pharmaceutical, and Environmental Sciences, University of Messina, Messina, Italy.
Vittorio CalabreseDepartment of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.
Rosanna Di PaolaDepartment of Veterinary Sciences, University of Messina, Messina, Italy.
Marika CordaroDepartment of Biomedical, Dental and Morphological and Functional Imaging, University of Messina, Messina, Italy.ORCID https://orcid.org/0000-0002-3980-0043

Funding

Piano di incentivi per la Ricerca, Linea Intervento 2 PIACERI, 2020-2022
6 · The paper itself

Abstract

scopeValproic acid (VPA) postnatal exposure in mice results in behavioral impairment, aberrant sensitivity to sensory stimuli, and self-harming behavior, hallmarks of autism. According to previous reports, Coriolus versicolor (CV) has a protective effect on the brain. The goal of the current investigation was to assess how CV affected the neurobehavioral and metabolic changes caused by VPA in mice. METHODS AND

resultsMice pups were injected with VPA at 14 days of age and orally administered CV at a dose of 200 mg/kg daily from 14 to 40 days of age. Mice pups were placed through behavioral tests during the trial to evaluate motor skill growth, nociceptive response, locomotion, anxiety, and cognition. Following behavioral testing, mice were killed, and the brain was removed and subjected to biochemical analyses (glutathione, malondialdehyde, and nitric oxide) and histopathological analysis. Additionally, to further investigate the role of the TLR-4/Myd88/NF-κB signaling pathway, we examined the modulation of this pathway and the alteration in gamma-amino butyric acid (GABA) production using Western blot analysis.

conclusionAccording to our research, CV daily administration greatly reduced behavioral alteration, reversed the disorganization of the cerebellum and hippocampus, and significantly improved the VPA-induced neuroinflammation via the TLR-4/Myd88/NF-κB signaling cascade.

Indexed as

Autistic DisorderBehavior, AnimalFunctional Foodgamma-Aminobutyric AcidPolyporaceaeAnimalsBrainDisease Models, AnimalMiceMyeloid Differentiation Factor 88NF-kappa BSignal TransductionToll-Like Receptor 4Valproic Acidgamma-Aminobutyric AcidMyd88 protein, mouseMyeloid Differentiation Factor 88NF-kappa BTlr4 protein, mouseToll-Like Receptor 4Valproic AcidautismbehaviorsGABAneuroinflammationTLR‐4valproic acid

Identifiers

PMID40462659
PMCPMC12134490

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.