Evidence map›Paper›PMID 40462897›Full record

ArticlebioRxiv : the preprint server for biology2025

Delayed forebrain excitatory and inhibitory neurogenesis in STRADA-related megalencephaly via mTOR hyperactivity.

Tong Pan, Grace Lin, Xuan Li, Debora VanHeyningen, John Clay Walker, Sahej Kohli, Aiswarya Saravanan, Amrita Kondur, Daniel C Jaklic, Saul Pantoja-Gutierrez and 6 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Tong PanDepartment of Pediatrics, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-8475-4437
Grace LinDepartment of Pediatrics, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA.
Xuan LiLaboratory of Human Retrovirology and Immunoinformatics, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
Debora VanHeyningenDepartment of Pediatrics, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA.
John Clay WalkerDepartment of Pediatrics, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA.
Sahej KohliDepartment of Pediatrics, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA.
Aiswarya SaravananDepartment of Pediatrics, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA.
Amrita KondurDepartment of Pediatrics, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA.
Daniel C JaklicDepartment of Pediatrics, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA.
Saul Pantoja-GutierrezDepartment of Pediatrics, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA.
Shivanshi VaidDepartment of Pediatrics, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA.
Julie SturzaDepartment of Pediatrics, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA.ORCID 0009-0006-1486-1890
Ken InokiLife Sciences Institute, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0001-8882-444X
Tomozumi ImamichiLaboratory of Human Retrovirology and Immunoinformatics, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.ORCID 0000-0002-1474-1796
Weizhong ChangLaboratory of Human Retrovirology and Immunoinformatics, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.ORCID 0000-0002-1413-2763
Louis T DangDepartment of Pediatrics, Michigan Medicine, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0003-4853-4952

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Eric R. Fearon · 1988 to 2026
$178.2M
Elucidating pathogenic mechanisms in STRADA-related brain malformation and epilepsyR01NS127829 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Louis Tuong Chinh Dang · 2022 to 2026
$2.1M
Lysosomal cholesterol-dependent anabolic regulationR01DK124709 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI INOKI, KEN · 2022 to 2025
$2.1M
Molecular mechanism of Rheb-dependent mTORC1 regulationR01GM145631 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI INOKI, KEN · 2022 to 2025
$1.8M
NCI NIH HHS P30 CA046592NIDDK NIH HHS R01 DK124709NIGMS NIH HHS R01 GM145631NINDS NIH HHS R01 NS127829
6 · The paper itself

Abstract

Biallelic pathogenic variants in

Indexed as

brain organoidcell fate specificationepilepsyinterneuron developmentMammalian target of rapamycinmechanistic target of rapamycinmTORmTORC1PMSE syndromeSTRADA

Identifiers

PMID40462897
PMCPMC12132401

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.