Evidence map›Paper›PMID 40462905›Full record

ArticlebioRxiv : the preprint server for biology2025

Application of post glycosylation modifying enzymes for mass spectrometry imaging of modified

Julia E Dreifus, Léa Chuzel, Edwin E Escobar, Grace Grimsley, Hongxia Bai, Andrew J Hanneman, Samantha L Fossa, Vanessa Gregory, Richard J Martin, Richard R Drake and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Julia E DreifusNew England Biolabs, Ipswich, MA 01938, USA.
Léa ChuzelNew England Biolabs, Ipswich, MA 01938, USA.
Edwin E EscobarNew England Biolabs, Ipswich, MA 01938, USA.
Grace GrimsleyMedical University of South Carolina, Charleston, SC 29425, USA.
Hongxia BaiMedical University of South Carolina, Charleston, SC 29425, USA.
Andrew J HannemanNew England Biolabs, Ipswich, MA 01938, USA.
Samantha L FossaNew England Biolabs, Ipswich, MA 01938, USA.
Vanessa GregoryNew England Biolabs, Ipswich, MA 01938, USA.
Richard J MartinIowa State University, Ames, IA 50011, USA.
Richard R DrakeMedical University of South Carolina, Charleston, SC 29425, USA.
Jeremy M FosterNew England Biolabs, Ipswich, MA 01938, USA.
Christopher H TaronNew England Biolabs, Ipswich, MA 01938, USA.

Funding

RESISTANCE &MODULATION OF LEVAMISOLE RECEPTOR CHANNELSR01AI047194 · NIAID · IOWA STATE UNIVERSITY · PI MARTIN, RICHARD JOHN · 2001 to 2021
$5.8M
Slo-1K channels, TRP-2 channels, emodepside and diethylcarbamazine in FilariaR01AI155413 · NIAID · IOWA STATE UNIVERSITY · PI Richard John Martin · 2020 to 2026
$2.7M
NIAID NIH HHS R01 AI047194NIAID NIH HHS R01 AI155413
6 · The paper itself

Abstract

Glycans are essential components of cells and are involved in innumerable biological processes. Their structural diversity and complexity present unique analytical challenges. Glycans are comprised of various types of monosaccharides that are linked together at different positions and with varied stereochemistry. In addition, glycans are frequently decorated with a diverse set of chemical modifications, termed post-glycosylation modifications (PGMs). Characterization of PGMs is essential for a thorough understanding of glycans, however, the technical challenges and low throughput of current methodologies have limited our understanding of these modifications. Here we demonstrate a novel approach for rapid visualization of specific PGMs present in tissue

Indexed as

biomarker screeningmass spectrometry imagingmodified N-glycansPost-glycosylation modification

Identifiers

PMID40462905
PMCPMC12132447

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.