Evidence map›Paper›PMID 40462921›Full record

ArticlebioRxiv : the preprint server for biology2025

Neuropeptidergic transmission shapes emergent properties of prefrontal cortical circuits underlying learning.

Miguel A Arenivar, Nathanyal Ross, Rodolfo J Flores, Sultan Zakariya, Zachary Wang, Hector E Yarur, Rufina Kore, Wilma V Richiez-Mateo, Aaron Limoges, Huikun Wang and 7 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Miguel A ArenivarUnit on Neuromodulation and Synaptic Integration, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-0970-3269
Nathanyal RossUnit on Neuromodulation and Synaptic Integration, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-7715-1542
Rodolfo J FloresUnit on Neuromodulation and Synaptic Integration, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD, USA.
Sultan ZakariyaUnit on Neuromodulation and Synaptic Integration, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD, USA.
Zachary WangUnit on Neuromodulation and Synaptic Integration, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD, USA.
Hector E YarurUnit on Neuromodulation and Synaptic Integration, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-8549-3315
Rufina KoreUnit on Neuromodulation and Synaptic Integration, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-3650-8207
Wilma V Richiez-MateoUnit on Neuromodulation and Synaptic Integration, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-8277-1893
Aaron LimogesUnit on Neuromodulation and Synaptic Integration, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-7987-7045
Huikun WangUnit on Neuromodulation and Synaptic Integration, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-8556-3504
Hector Bravo-RiveraUnit on Neuromodulation and Synaptic Integration, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-7882-3945
Diana Agbor-EnohUnit on Neuromodulation and Synaptic Integration, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD, USA.
Juan Enriquez-TrabaUnit on Neuromodulation and Synaptic Integration, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-7387-3433
Xinglong GuMolecular Genetics Section, Laboratory of Sensory Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.
Bruno B AverbeckSection on Learning and Decision Making, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0002-3976-8565
Yulong LiIDG/McGovern Institute for Brain Research, Peking University, Beijing, China.
Hugo A TejedaUnit on Neuromodulation and Synaptic Integration, National Institute of Mental Health Intramural Research Program, National Institutes of Health, Bethesda, MD, USA.

Funding

Trans-synaptic optical control of user-defined synaptic connectionsUF1NS133763 · NINDS · WASHINGTON UNIVERSITY · PI COPITS, BRYAN, O'NEILL, PATRICK ROSS · 2023 to 2023
$1.7M
NINDS NIH HHS UF1 NS133763
6 · The paper itself

Abstract

The prefrontal cortex (PFC) is essential for top-down control of affect and its dysfunction is implicated in many psychiatric disorders. Inhibitory interneurons expressing somatostatin have been implicated in cognition, affect, and disease. However, somatostatin's function as a neuropeptide transmitter remains unclear. Here, we investigated the contribution of somatostatin neurotransmission in differentiating between salient (rewarding or aversive) and neutral outcomes. Monitoring somatostatin release and somatostatin receptor antagonism revealed time-dependent regulation of outcome-specific associative learning during acquisition. We found that somatostatin transmission enables configural representations incorporating a salient, aversive outcome in prefrontal cortical neurons, and a threat-driven shift in population-level network activity

Identifiers

PMID40462921
PMCPMC12132504

What Socratic holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.