Evidence map›Paper›PMID 40462941›Full record

ArticlebioRxiv : the preprint server for biology2025

Ferret model of bleomycin-induced lung injury shares features of human idiopathic pulmonary fibrosis.

Shuang Wu, Ian Drive, Meihui Luo, Hikaru Miyazaki, Smitha Shambhu, Dimitry Popov, Liyuan Yang, Jing Wang, Jia Ma, Junfeng Guo and 9 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Shuang WuDepartment of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
Ian DriveGordian Biotechnology, 486 Cabot Rd, South San Francisco, CA 94080, USA.
Meihui LuoDepartment of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
Hikaru MiyazakiGordian Biotechnology, 486 Cabot Rd, South San Francisco, CA 94080, USA.
Smitha ShambhuGordian Biotechnology, 486 Cabot Rd, South San Francisco, CA 94080, USA.
Dimitry PopovGordian Biotechnology, 486 Cabot Rd, South San Francisco, CA 94080, USA.
Liyuan YangDepartment of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
Jing WangDepartment of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
Jia MaDepartment of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
Junfeng GuoDepartment of Radiology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
Jarron AthaDepartment of Radiology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
Aleksandra TataDepartment of Cell Biology, Duke University School of Medicine, Durham, NC 27708, USA.
Eric A HoffmanDepartment of Radiology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.
Yujiong WangKey Laboratory of Ministry of Education for Conservation and Utilization of Special Biological Resources in Western China, College of Life Science, Ningxia University, Yinchuan, Ningxia 750021, PR China.
Purushothama Rao TataDepartment of Cell Biology, Duke University School of Medicine, Durham, NC 27708, USA.
Martin B JensenGordian Biotechnology, 486 Cabot Rd, South San Francisco, CA 94080, USA.
John F EngelhardtDepartment of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.ORCID 0000-0003-4837-0337
Vishwaraj SontakeGordian Biotechnology, 486 Cabot Rd, South San Francisco, CA 94080, USA.
Xiaoming LiuDepartment of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.ORCID 0000-0002-3902-9105

Funding

Molecular control of a novel transitional cell state in alveolar regenerationR01HL153375 · NHLBI · DUKE UNIVERSITY · PI Purushothama Rao Tata · 2020 to 2026
$3.4M
Biology of Submucosal Gland Stem Cells in the AirwayR01HL165404 · NHLBI · UNIVERSITY OF IOWA · PI ENGELHARDT, JOHN F · 2022 to 2025
$2.9M
Cellular crosstalk and molecular mechanisms in the initiation and progression of pulmonary fibrosisR01HL160939 · NHLBI · DUKE UNIVERSITY · PI TATA, PURUSHOTHAMA RAO · 2022 to 2025
$2.1M
NHLBI NIH HHS R01 HL153375NHLBI NIH HHS R01 HL160939NHLBI NIH HHS R01 HL165404
6 · The paper itself

Abstract

Idiopathic pulmonary fibrosis (IPF) is a debilitating lung disease with limited therapeutic options. The development of effective therapies has been hindered by the lack of models that recapitulate key features of human disease. Here we report a bleomycin-induced ferret PF model characterized by an irreversible decrease in pulmonary compliance and an increase of opacification, accompanied by "honeycomb cyst-like" structures and "proximalization" of distal lung epithelium. Cellular and molecular analysis by single-nucleus RNA sequencing revealed a significant shift in distal lung epithelium towards proximal epithelial phenotype. Importantly, a histopathological pattern of bronchiolization encompassing divergent atypical epithelial cells and KRT17

Indexed as

bleomycinbronchiolizationferretIdiopathic pulmonary fibrosissingle nucleus RNA sequencing

Identifiers

PMID40462941
PMCPMC12132224

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.