Evidence map›Paper›PMID 40463100›Full record

ArticlebioRxiv : the preprint server for biology2025

Multiscale patterning of a model apical extracellular matrix revealed by systematic endogenous protein tagging.

James Matthew Ragle, Murugesan Pooranachithra, Guinevere E Ashley, Emma Cadena, Batia Blank, Katelyn Kang, Cincy Chen, Aditree R Bhowmick, Soraya H Mercado, Tabatha E Wells and 3 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

James Matthew RagleDepartment of Molecular Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA 95064.ORCID 0000-0002-6626-2615
Murugesan PooranachithraDepartment of Cell and Developmental Biology, School of Biological Sciences, University of California San Diego, La Jolla, CA 92093.ORCID 0000-0003-3506-7785
Guinevere E AshleyDepartment of Molecular Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA 95064.ORCID 0000-0002-3983-5553
Emma CadenaDepartment of Molecular Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA 95064.ORCID 0009-0005-8000-7839
Batia BlankDepartment of Molecular Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA 95064.
Katelyn KangDepartment of Cell and Developmental Biology, School of Biological Sciences, University of California San Diego, La Jolla, CA 92093.
Cincy ChenDepartment of Cell and Developmental Biology, School of Biological Sciences, University of California San Diego, La Jolla, CA 92093.
Aditree R BhowmickDepartment of Molecular Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA 95064.
Soraya H MercadoDepartment of Molecular Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA 95064.
Tabatha E WellsDepartment of Molecular Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA 95064.
John C ClancyDepartment of Molecular Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA 95064.ORCID 0000-0003-2867-9740
Andrew D ChisholmDepartment of Cell and Developmental Biology, School of Biological Sciences, University of California San Diego, La Jolla, CA 92093.ORCID 0000-0001-5091-0537
Jordan D WardDepartment of Molecular Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA 95064.ORCID 0000-0001-9870-8936

Funding

Maintenance and Repair of the C. elegans SkinR35GM134970 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHISHOLM, ANDREW D · 2020 to 2024
$2.1M
Mechanisms of nematode moltingR01GM138701 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI WARD, JORDAN DAVID · 2020 to 2024
$1.6M
Illuminating apical extracellular matrix structure and biogenesisR21OD033663 · OD · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI CHISHOLM, ANDREW D, WARD, JORDAN DAVID · 2022 to 2023
$429k
NIGMS NIH HHS R01 GM138701NIGMS NIH HHS R35 GM134970NIH HHS R21 OD033663
6 · The paper itself

Abstract

Barrier epithelia are shielded from the external environment by their apical extracellular matrices (aECMs). The molecular complexity of aECMs has challenged understanding of their organization

Indexed as

collagenCRISPRecdysismatrisomeZP protein

Identifiers

PMID40463100
PMCPMC12132373

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.