ArticlebioRxiv : the preprint server for biology2025
Multiscale patterning of a model apical extracellular matrix revealed by systematic endogenous protein tagging.
James Matthew Ragle, Murugesan Pooranachithra, Guinevere E Ashley, Emma Cadena, Batia Blank, Katelyn Kang, Cincy Chen, Aditree R Bhowmick, Soraya H Mercado, Tabatha E Wells and 3 more
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from itWhat it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
13 authors.
James Matthew RagleDepartment of Molecular Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA 95064.ORCID 0000-0002-6626-2615 Murugesan PooranachithraDepartment of Cell and Developmental Biology, School of Biological Sciences, University of California San Diego, La Jolla, CA 92093.ORCID 0000-0003-3506-7785 Guinevere E AshleyDepartment of Molecular Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA 95064.ORCID 0000-0002-3983-5553 Emma CadenaDepartment of Molecular Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA 95064.ORCID 0009-0005-8000-7839 Batia BlankDepartment of Molecular Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA 95064.
Katelyn KangDepartment of Cell and Developmental Biology, School of Biological Sciences, University of California San Diego, La Jolla, CA 92093.
Cincy ChenDepartment of Cell and Developmental Biology, School of Biological Sciences, University of California San Diego, La Jolla, CA 92093.
Aditree R BhowmickDepartment of Molecular Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA 95064.
Soraya H MercadoDepartment of Molecular Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA 95064.
Tabatha E WellsDepartment of Molecular Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA 95064.
John C ClancyDepartment of Molecular Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA 95064.ORCID 0000-0003-2867-9740 Andrew D ChisholmDepartment of Cell and Developmental Biology, School of Biological Sciences, University of California San Diego, La Jolla, CA 92093.ORCID 0000-0001-5091-0537 Jordan D WardDepartment of Molecular Cell and Developmental Biology, University of California Santa Cruz, Santa Cruz, CA 95064.ORCID 0000-0001-9870-8936 Funding
Maintenance and Repair of the C. elegans SkinR35GM134970 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHISHOLM, ANDREW D · 2020 to 2024
$2.1MMechanisms of nematode moltingR01GM138701 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI WARD, JORDAN DAVID · 2020 to 2024
$1.6MIlluminating apical extracellular matrix structure and biogenesisR21OD033663 · OD · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI CHISHOLM, ANDREW D, WARD, JORDAN DAVID · 2022 to 2023
$429kNIGMS NIH HHS R01 GM138701NIGMS NIH HHS R35 GM134970NIH HHS R21 OD033663
6 · The paper itselfAbstract
Barrier epithelia are shielded from the external environment by their apical extracellular matrices (aECMs). The molecular complexity of aECMs has challenged understanding of their organization
Indexed as
collagenCRISPRecdysismatrisomeZP protein
Identifiers
PMID40463100
PMCPMC12132373
What Socratic holds
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