Evidence map›Paper›PMID 40463157›Full record

ArticlebioRxiv : the preprint server for biology2025

First Generation Tools for the Modeling of Capicua (CIC) - Family Fusion Oncoprotein-Driven Cancers.

Cuyler Luck, Kyle A Jacobs, Julia Riad, Christopher D Macaraig, Rovingaile Kriska M Ponce, Ross A Okimoto

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Cuyler LuckBiomedical Sciences Graduate Program, University of California, San Francisco, CA, USA.ORCID 0000-0002-1150-0057
Kyle A JacobsBiomedical Sciences Graduate Program, University of California, San Francisco, CA, USA.ORCID 0000-0002-4411-7855
Julia RiadDepartment of Medicine, University of California, San Francisco, CA, USA.
Christopher D MacaraigDepartment of Medicine, University of California, San Francisco, CA, USA.
Rovingaile Kriska M PonceDepartment of Medicine, University of California, San Francisco, CA, USA.ORCID 0000-0001-6122-4153
Ross A OkimotoDepartment of Medicine, University of California, San Francisco, CA, USA.ORCID 0000-0002-4467-8476

Funding

Restorative practice in repairing harm and promoting safe and inclusive practices in the laboratory.T32GM136547 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Adrian Erlebacher, Anita Sil · 2020 to 2026
$4.5M
Therapeutic degradation of Capicua (CIC) fused oncoproteins in undifferentiated sarcomasR37CA255453 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Ross Okimoto · 2021 to 2026
$2.7M
Leveraging Retained Partner Gene Function to Effectively Target CIC-rearranged Fusion OncoproteinsF31CA287493 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LUCK, CUYLER · 2024 to 2025
$92k
NCI NIH HHS F31 CA287493NCI NIH HHS R37 CA255453NIGMS NIH HHS T32 GM136547
6 · The paper itself

Abstract

Clinical divergence between patients harboring

Indexed as

ATXN1:DUX4capicuaCIC:DUX4CIC:LEUTXCIC:NUTM1fusionmodelplasmidsarcomasynthetic

Identifiers

PMID40463157
PMCPMC12132549

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.