Evidence map›Paper›PMID 40463187›Full record

ArticlebioRxiv : the preprint server for biology2025

Nickel binding to c-Src SH3 domain facilitates crystallization.

Xander Calicdan, Oriana S Fisher, Byung Hak Ha, Titus J Boggon, Amy L Stiegler

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Xander CalicdanDepartment of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT, USA.ORCID 0009-0009-5440-5955
Oriana S FisherDepartment of Molecular Biology and Biochemistry, Wesleyan University, Middletown, CT, USA.ORCID 0000-0003-3215-0831
Byung Hak HaDepartment of Pharmacology, Yale University, New Haven, CT, USA.ORCID 0000-0001-6594-0835
Titus J BoggonDepartment of Pharmacology, Yale University, New Haven, CT, USA.ORCID 0000-0003-2862-1637
Amy L StieglerDepartment of Pharmacology, Yale University, New Haven, CT, USA.ORCID 0000-0003-0453-6104

Funding

X-ray Scattering Technology CoreP30GM133893 · NIGMS · BROOKHAVEN SCIENCE ASSOC-BROOKHAVEN LAB · PI Vivian Stojanoff · 2019 to 2026
$38.6M
Structure-directed investigations into the regulation of Ste20 kinasesR01GM102262 · NIGMS · YALE UNIVERSITY · PI BOGGON, TITUS JONATHON · 2012 to 2025
$4.2M
Structural and functional basis of bacterial transcriptional regulationR35GM150644 · NIGMS · WESLEYAN UNIVERSITY · PI Oriana S Fisher · 2023 to 2026
$1.6M
NIGMS NIH HHS P30 GM133893NIGMS NIH HHS R01 GM102262NIGMS NIH HHS R35 GM150644
6 · The paper itself

Abstract

Numerous X-ray crystal structures of the c-Src SH3 domain have provided a large sampling of atomic-level information for this important signaling domain. Multiple crystal forms have been reported, with variable crystal lattice contacts and chemical crystallization conditions. Here, we report a unique crystal structure of Src SH3 domain in trigonal space group

Indexed as

anomalous signalcrystal structurec-Src tyrosine kinasedimerizationnickel coordinationSH3 domain

Identifiers

PMID40463187
PMCPMC12132234

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.