Evidence map›Paper›PMID 40463221›Full record

ArticlebioRxiv : the preprint server for biology2025

Characterization of cytokine treatment on human pancreatic islets by top-down proteomics.

Ashley N Ives, Tyler Sagendorf, Lorenz Nierves, Tai-Tu Lin, Ercument Dirice, Rohit N Kulkarni, Ljiljana Paša-Tolić, Wei-Jun Qian, James M Fulcher

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Ashley N IvesEnvironmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, WA 99354, USA.
Tyler SagendorfBiological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA.
Lorenz NiervesBiological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA.
Tai-Tu LinBiological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA.
Ercument DiriceDepartment of Pharmacology and Medicine, New York Medical College School of Medicine, Valhalla, NY 10595, USA.
Rohit N KulkarniIslet Cell and Regenerative Biology, Joslin Diabetes Center, Boston, MA 02215, USA.
Ljiljana Paša-TolićEnvironmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, WA 99354, USA.
Wei-Jun QianBiological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99354, USA.
James M FulcherEnvironmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, WA 99354, USA.ORCID 0000-0001-9033-3623

Funding

Robust Mass Spectrometric Protein/Peptide Assays for Type 1 Diabetes Clinical ApplicationsU01DK137113 · NIDDK · BATTELLE PACIFIC NORTHWEST LABORATORIES · PI Wei-Jun Qian, Jun Qu · 2023 to 2026
$3.8M
Pathways and Regulators Driving Progressive Islet Cell Dysfunction in Type 1 DiabetesR01DK122160 · NIDDK · BATTELLE PACIFIC NORTHWEST LABORATORIES · PI ROHIT N. KULKARNI, CLAYTON E MATHEWS · 2019 to 2026
$3.7M
Discovery and Roles of In Situ Islet Neoantigens in Human Type 1 DiabetesR01DK135081 · NIDDK · UNIVERSITY OF FLORIDA · PI CLAYTON E MATHEWS, DAVID A OSTROV · 2023 to 2026
$2.8M
NIDDK NIH HHS R01 DK122160NIDDK NIH HHS R01 DK135081NIDDK NIH HHS U01 DK137113
6 · The paper itself

Abstract

Type 1 diabetes (T1D) results from autoimmune-mediated destruction of insulin-producing β cells in the pancreatic islet. This process is modulated by pro-inflammatory cytokine signaling, which have been previously shown to alter protein expression in

Indexed as

glucagonhormone processingislettop-down proteomics

Identifiers

PMID40463221
PMCPMC12132588

What Socratic holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.