ReviewFrontiers in immunology2025
Cross-talk between cardiac lymphatics and immune cells regulates inflammatory response and cardiac recovery after myocardial infarction.
Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Inflammation-Mediated Mechanisms of Arrhythmias After Acute Myocardial Infarction.Reviews in cardiovascular medicine · 2026Review
- Cardiac lymphatics: functional plasticity in development, disease, and precision-targeted therapies.Basic research in cardiology · 2026Review
- Myocardial ischemia-reperfusion injury after acute myocardial infarction: spatiotemporal mechanisms and endotype-matched multi-target modulation by compounds from traditional Chinese medicine.Frontiers in cardiovascular medicine · 2026Review
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Myocardial infarction (MI) is a life-threatening disease with high morbidity and mortality, closely associated with immune-inflammatory responses. As essential pathways for immune cell clearance and interstitial fluid drainage, lymphatic vessels are critical in regulating tissue fluid homeostasis and systemic immune surveillance. Cardiac lymphatics interact with immune cells, directly and indirectly, to mediate post-MI inflammation, participate in the clearance of necrotic tissue, and contribute to cardiac remodeling. Studies indicate that after MI, promoting cardiac lymphangiogenesis can accelerate the clearance of infiltrated immune cells, reduce the production of pro-inflammatory cytokines, improve myocardial edema, mitigate inflammatory responses and fibrosis, and support recovery of cardiac function. Meanwhile, immune cells regulate the structure and function of cardiac lymphatics, influencing lymphangiogenesis and drainage efficiency. The interaction between cardiac lymphatics and immune cells is crucial for myocardial repair post-MI. This review first systematically summarizes the structure and function of cardiac lymphatics, then sorting the relationship between cardiac lymphatics and immune cells and their roles in myocardial repair after MI and finally proposes therapeutic strategies targeting the interaction between cardiac lymphatics and immune cells in MI treatment, to provide prospective insights for the prevention and treatment of MI in the future.
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Registered trials
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