Evidence map›Paper›PMID 40463529›Full record

ArticlemedRxiv : the preprint server for health sciences2025

Protein kinase C eta enhances Golgi-localized signaling and is associated with Alzheimer's disease using a recessive mode of inheritance.

Maria Celeste Gauron, Dmitry Prokopenko, Sanghun Lee, Sarah A Wolfe, Julian Hecker, Julian Willett, Mohammad Waqas, Gema Lordén, Yimin Yang, Joshua E Mayfield and 10 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Maria Celeste GauronDepartment of Pharmacology, University of California; San Diego, La Jolla, CA, USA.
Dmitry ProkopenkoGenetics and Aging Research Unit and the McCance Center for Brain Health, Department of Neurology, Massachusetts General Hospital; Charlestown, MA, USA.
Sanghun LeeDepartment of Medical Consilience, Graduate School, Dankook University; South Korea.
Sarah A WolfeDepartment of Pharmacology, University of California; San Diego, La Jolla, CA, USA.
Julian HeckerHarvard Medical School; Boston, MA, USA.
Julian WillettGenetics and Aging Research Unit and the McCance Center for Brain Health, Department of Neurology, Massachusetts General Hospital; Charlestown, MA, USA.
Mohammad WaqasGenetics and Aging Research Unit and the McCance Center for Brain Health, Department of Neurology, Massachusetts General Hospital; Charlestown, MA, USA.
Gema LordénDepartment of Pharmacology, University of California; San Diego, La Jolla, CA, USA.
Yimin YangDepartment of Pharmacology, University of California; San Diego, La Jolla, CA, USA.
Joshua E MayfieldDepartment of Pharmacology, University of California; San Diego, La Jolla, CA, USA.
Isabel CastanhoHarvard Medical School; Boston, MA, USA.
Kristina MullinGenetics and Aging Research Unit and the McCance Center for Brain Health, Department of Neurology, Massachusetts General Hospital; Charlestown, MA, USA.
Sarah MorganDepartment of Pathology, Beth Israel Deaconess Medical Center; Boston, MA, USA.
Georg HahnDepartment of Biostatistics, Harvard T.H. Chan School of Public Health; Boston, MA, USA.
Dawn L DemeoHarvard Medical School; Boston, MA, USA.
Winston HideHarvard Medical School; Boston, MA, USA.
Lars BertramLübeck Interdisciplinary Platform for Genome Analytics, Institutes of Neurogenetics and Cardiogenetics, University of Lübeck; Lübeck, Germany.
Christoph LangeHarvard Medical School; Boston, MA, USA.
Alexandra C NewtonDepartment of Pharmacology, University of California; San Diego, La Jolla, CA, USA.
Rudolph E TanziGenetics and Aging Research Unit and the McCance Center for Brain Health, Department of Neurology, Massachusetts General Hospital; Charlestown, MA, USA.

Funding

TRAINING GRANT IN GENETICST32GM007748 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI Anne O'Donnell-Luria, Louise Wilkins-Haug · 1985 to 2026
$12.0M
Molecular Mechanisms of Cell SignalingR35GM122523 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ALEXANDRA C. NEWTON · 2017 to 2026
$6.7M
NIGMS NIH HHS R35 GM122523NIGMS NIH HHS T32 GM007748
6 · The paper itself

Abstract

The identification of Alzheimer's disease (AD)-associated genomic variants has provided powerful insight into disease etiology. Genome-wide association studies (GWAS) for AD have successfully identified new targets but have almost exclusively utilized additive genetic models. Here, we performed a family-based GWAS under a recessive inheritance model using whole genome sequencing from families affected by AD. We found that the variant, rs7161410, located in an intron of the

Identifiers

PMID40463529
PMCPMC12132147

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.