ArticleNature and science of sleep2025
The Hourly Apnea-Hypopnea Duration Better Correlates with OSA-Related Nocturnal Hypoxemia and Excessive Daytime Sleepiness Rather Than AHI.
Article in Nature and science of sleep, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- miR-1180-3p as a biomarker of obstructive sleep apnea hypopnea syndrome and its role in chronic intermittent hypoxia-induced vascular injury.Clinics (Sao Paulo, Brazil) · 2026Article
- Article
- Determinants of MSLT- defined sleepiness in OSA patients with neuropsycological findings.Sleep & breathing = Schlaf & Atmung · 2025Article
- The dose-effect and clinical prediction of the longest apnea duration driving the decrease of blood oxygen: a large sample OSA study with 34-second and 52-second cut-off values was established.Frontiers in physiology · 2025Article
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Authors and funding
7 authors.
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Abstract
Background: The apnea-hypopnea index (AHI) has limitations in assessing nocturnal hypoxemia and excessive daytime sleepiness (EDS) in obstructive sleep apnea (OSA) patients. This study evaluated whether hourly apnea-hypopnea duration (HAD) and mean apnea-hypopnea duration (MAD) could complement or outperform AHI. Methods: This study included 1069 OSA patients, of whom 754 completed the Epworth Sleepiness Scale (ESS). Multivariable regression models evaluated the associations between AHI, MAD, HAD, and nocturnal hypoxemia, and standardized Results: Nocturnal hypoxemia was observed in 317 participants (29.65%). Patients with nocturnal hypoxemia had significantly higher AHI (43.19 ± 18.41 vs 21.78 ± 14.73 events/hour, P < 0.001) and longer HAD (16.71 ± 7.48 vs 8.24 ± 5.40 minutes, P < 0.001). After adjusting for age, sex, and BMI, AHI and HAD were still significantly associated with nocturnal hypoxemia (P < 0.05). Standardized Conclusion: The HAD better correlates with OSA-related nocturnal hypoxemia and EDS rather than AHI. The duration of respiratory events warrants more investigation in clinical assessment.
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