Evidence map›Paper›PMID 40464151›Full record

ArticleEpilepsia2025

Harvard Electroencephalography Database: A comprehensive clinical electroencephalographic resource from four Boston hospitals.

Chenxi Sun, Jin Jing, Niels Turley, Callison Alcott, Wan-Yee Kang, Andrew J Cole, Daniel M Goldenholz, Alice Lam, Edilberto Amorim, Catherine Chu and 25 more

Abstract read
In one paragraph

Article in Epilepsia, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors.

Chenxi SunDepartment of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-1762-0877
Jin JingDepartment of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Niels TurleyDepartment of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.ORCID https://orcid.org/0009-0009-4806-578X
Callison AlcottHarvard Medical School, Boston, Massachusetts, USA.
Wan-Yee KangDepartment of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Andrew J ColeHarvard Medical School, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-0828-826X
Daniel M GoldenholzDepartment of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-8370-2758
Alice LamHarvard Medical School, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0001-7754-4637
Edilberto AmorimUniversity of California, San Francisco, San Francisco, California, USA.
Catherine ChuHarvard Medical School, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0001-7670-9313
Sydney CashHarvard Medical School, Boston, Massachusetts, USA.
Valdery Moura JuniorHarvard Medical School, Boston, Massachusetts, USA.
Aditya GuptaDepartment of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-5243-368X
Manohar GhantaDepartment of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Bruce NearingDepartment of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Fábio A NascimentoDepartment of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Aaron StruckDepartment of Neurology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Jennifer KimDepartment of Neurology, Yale School of Medicine, New Haven, Connecticut, USA.
Shadi SartipiHarvard Medical School, Boston, Massachusetts, USA.
Alexandra-Maria TautonHarvard Medical School, Boston, Massachusetts, USA.
Marta FernandesHarvard Medical School, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0002-7203-2832
Haoqi SunDepartment of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Grace BayasDepartment of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.
Kaileigh GallagherDepartment of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.ORCID https://orcid.org/0009-0005-2802-9790
Joost B WagenaarDepartment of Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Nishant SinhaDepartment of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Christopher Lee-MesserDepartment of Neurology, Stanford University School of Medicine, Stanford, California, USA.
Christine Tsien SilversAmazon Web Services, Seattle, Washington, USA.
Bharath GunapatiAmazon Web Services, Seattle, Washington, USA.
Jonathan RosandHarvard Medical School, Boston, Massachusetts, USA.
Jurriaan PetersHarvard Medical School, Boston, Massachusetts, USA.
Tobias LoddenkemperHarvard Medical School, Boston, Massachusetts, USA.
Jong Woo LeeHarvard Medical School, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0001-5283-7476
Sahar ZafarHarvard Medical School, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0001-5252-5376
M Brandon WestoverDepartment of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA.ORCID https://orcid.org/0000-0003-4803-312X

Funding

Bridge2AI: Patient-Focused Collaborative Hospital Repository Uniting Standards (CHoRUS) for Equitable AIOT2OD032701 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI BIHORAC, AZRA, CLERMONT, GILLES · 2022 to 2025
$24.6M
Late-onset Unexplained Epilepsy as a Risk Factor for DementiaR01NS130119 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Alice D Lam · 2023 to 2026
$8.7M
Data-Driven Sleep Biomarkers of Brain Health, Heart Health, and MortalityR01HL161253 · NHLBI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI CLIFFORD, GARI DAVID, MIGNOT, EMMANUEL J · 2022 to 2025
$8.3M
Comparative Safety of Seizure Prophylaxis within the Medicare ProgramR01AG073410 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Lidia Maria Veras Rocha de Moura · 2021 to 2026
$4.1M
Low Neurophysiologic Resistance to Anesthetics as a Marker of Preclinical/Prodromal Alzheimer's Disease and Neurovascular Pathology, Delirium risk and InattentionR01AG073598 · NIA · STANFORD UNIVERSITY · PI Miles Berger · 2022 to 2026
$3.8M
Integrative Motor Activity Biomarker for the Risk of Alzheimer's RiskRF1AG064312 · NIA · BRIGHAM AND WOMEN'S HOSPITAL · PI HU, KUN · 2019 to 2019
$3.6M
The Juvenile Myoclonic Epilepsy Connectome ProjectR01NS111022 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI STRUCK, AARON F · 2020 to 2024
$3.1M
Treating hyperexcitability in Alzheimer’s disease with levetiracetam to improve brain function and cognitionR01AG060987 · NIA · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SHAFI, MOUHSIN · 2019 to 2023
$3.0M
Prospective Validation of Neurophysiologic Outcome Prediction in Acute Brain InjuryR01NS126282 · NINDS · BETH ISRAEL DEACONESS MEDICAL CENTER · PI Aaron F Struck, Michael Brandon Westover · 2023 to 2026
$2.9M
Epilepsy Seizure Detection with Innovative Tripolar EEG (tEEG)U44NS121559 · NINDS · CREMEDICAL CORPORATION · PI BESIO, WALTER GRANT · 2021 to 2024
$2.5M
Establishing a Brain Health Index from the Sleep ElectroencephalogramRF1NS120947 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI CASH, SYDNEY S, THOMAS, ROBERT JOSEPH · 2021 to 2021
$2.4M
Development and Validation of a Nocturnal Sleep Signature for the Diagnosis of Idiopathic HypersomniaR61NS130215 · NINDS · BOSTON CHILDREN'S HOSPITAL · PI Kiran Prasad Maski · 2024 to 2026
$2.0M
American Heart Association 20CDA35310297American Heart Association 24DIVSUP1274116Beth Israel Deaconess Medical CenterCures Within Reach 2022CAL-AmorimHellman FoundationNational Science Foundation 2014431NHLBI NIH HHS R01 HL161253NIA NIH HHS K23 AG063899NIA NIH HHS R01 AG060987NIA NIH HHS R01 AG073410NIA NIH HHS R01 AG073598NIA NIH HHS RF1 AG064312NIBIB NIH HHS R01 EB032820NICHD NIH HHS R21 HD115285NIH HHS 1OT2OD032701NIH HHS K23NS119794NIH HHS K23NS124656NIH HHS K99NS138680NIH HHS OT2 OD032701NIH HHS R01AG073410NIH HHS R01AG073598NIH HHS R01HL161253NIH HHS R01NS126282NIH HHS R01NS128342NIH HHS R01NS130119NIH HHS R01NS131347NIH HHS RF1AG064312NIH HHS RF1NS120947NINDS NIH HHS K23 NS104267NINDS NIH HHS K23 NS119794NINDS NIH HHS K23 NS124656NINDS NIH HHS K99 NS138680NINDS NIH HHS R01 NS111022NINDS NIH HHS R01 NS120947NINDS NIH HHS R01 NS126282NINDS NIH HHS R01 NS128342NINDS NIH HHS R01 NS130119NINDS NIH HHS R01 NS131347NINDS NIH HHS R61 NS130215NINDS NIH HHS RF1 NS120947NINDS NIH HHS U44 NS121559U.S. Department of Defense ERP 220036U.S. Department of Defense W81XWH-19-1-0861U.S. Department of Defense W81XWH-21-C-0075Zoll Foundation
6 · The paper itself

Abstract

objectiveThis article presents the Harvard Electroencephalography Database (HEEDB), a large-scale, deidentified, and standardized electroencephalographic (EEG) resource supporting artificial intelligence-driven and reproducible research in epilepsy and broader clinical neuroscience.

methodsHEEDB aggregates more than 280 000 EEG recordings from more than 108 000 patients across four Harvard-affiliated hospitals. Data are harmonized using the Brain Imaging Data Structure and hosted on the Brain Data Science Platform. EEG data are linked with clinical notes, International Classification of Diseases, 10th Revision codes, medications, and EEG reports. Deidentification follows Health Insurance Portability and Accountability Act Safe Harbor standards.

resultsThe database includes routine, epilepsy monitoring unit, and intensive care unit EEGs across all age groups, with 73% linked to deidentified clinical reports and 96% of those matched to recordings. Findings are extracted using expert curation, regular expressions, and medical natural language processing models. Auxiliary data include diagnoses, medications, and hospital course, supporting multimodal analysis. SIGNIFICANCE: HEEDB fills a critical gap in EEG data availability for epilepsy research. By enabling large-scale, privacy-compliant, and clinically relevant analysis, it accelerates the development of diagnostic tools, improves training datasets for machine learning, and promotes data-sharing in alignment with FAIR (Findable, Accessible, Interoperable, Reusable) and National Institutes of Health data policies.

Indexed as

Databases, FactualElectroencephalographyEpilepsyAdolescentAdultAgedBostonChildChild, PreschoolFemaleHumansInfantMaleMiddle AgedYoung AdultAI for neurologyData‐driven EEG analysisDeidentified clinical dataEEG data platformEEG large‐scale database

Identifiers

PMID40464151
PMCPMC12455399

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.