ArticleOdontology2026
Waterpipe smoke condensate activates the oncogenes and promotes epithelial-mesenchymal transition to cause oral cancer.
Article in Odontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- DNA methyltransferases expressions in mice tongue exposed to waterpipe smoke.Journal of applied oral science : revista FOB · 2026Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Oral squamous cell carcinoma (OSCC) is a significant health challenge, particularly in the Indian subcontinent, where it is the second leading cause of cancer. Smoking, including waterpipe tobacco smoking, is a major risk factor for OSCC and contributes to the onset of malignancy through the absorption of carcinogenic compounds present in tobacco smoke. This study investigated the role of the oncogene Yes-associated protein 1 (YAP1) signaling pathway in OSCC progression, focusing on how exposure to waterpipe smoke condensate (WPSC) influences cellular proliferation, epithelial-mesenchymal transition (EMT), and YAP1 activity. Using immortalized human oral keratinocytes (HOK) and OSCC cell lines, we found that WPSC significantly enhanced cell proliferation, increased colony formation, and elevated YAP1 expression compared to controls. Notably, WPSC treatment resulted in the downregulation of the epithelial marker E-cadherin and the upregulation of mesenchymal markers, indicating a shift towards an invasive phenotype. Further bioinformatic analysis of The Cancer Genome Atlas (TCGA) dataset confirmed that YAP1 is frequently altered in HNSCC, highlighting its role in OSCC carcinogenesis. Our findings establish YAP1 as a central mediator in the response of oral keratinocytes to the oncogenic effects of waterpipe smoking, promoting EMT and enhancing invasive characteristics of OSCC cells. These results underscore the therapeutic potential of targeting the YAP1 signaling pathway in OSCC treatment, particularly in individuals exposed to waterpipe smoke. Future research should elucidate the molecular mechanisms of WPSC-induced YAP1 activation and EMT, paving the way for innovative therapeutic strategies to combat OSCC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.