Evidence map›Paper›PMID 40464975›Full record

ArticleArchives of toxicology2025

A novel polypeptide from stony coral Goniopora columna inhibits thrombosis by interfering with the contact-kinin pathway.

Qian Chen, Congshuang Deng, Xiaoshan Huang, Kaixun Cao, Hanbin Chen, Yang Chen, Mehwish Khalid, Qiuyue Xu, Qiumin Lu, Ziyi Wang and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Archives of toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Qian Chen *Center for Evolution and Conservation Biology, Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou, 511458, China.
Congshuang Deng *Shenzhen Academy of Environmental Sciences, Shenzhen, 518022, Guangdong, China.
Xiaoshan Huang *Engineering Laboratory of Peptides of Chinese Academy of Sciences, Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), State Key Laboratory of Genetic Evolution & Animal Models, Sino-African Joint Research Center, and New Cornerstone Science Laboratory, National Resource Center for Non-Human Primates, Kunming Institute of Zoology, The Chinese Academy of Sciences, No.17 Longxin Road, Kunming, 650201, Yunnan, China.
Kaixun CaoCollege of Life Sciences, Nanjing Agricultural University, Nanjing, 210095, Jiangsu, China.
Hanbin ChenDepartment of Pharmacology, Joint Laboratory of Guangdong-Hong Kong Universities for Vascular Homeostasis and Diseases, School of Medicine, Southern University of Science and Technology, Shenzhen, 518055, Guangdong, China.
Yang ChenEngineering Laboratory of Peptides of Chinese Academy of Sciences, Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), State Key Laboratory of Genetic Evolution & Animal Models, Sino-African Joint Research Center, and New Cornerstone Science Laboratory, National Resource Center for Non-Human Primates, Kunming Institute of Zoology, The Chinese Academy of Sciences, No.17 Longxin Road, Kunming, 650201, Yunnan, China.
Mehwish KhalidEngineering Laboratory of Peptides of Chinese Academy of Sciences, Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), State Key Laboratory of Genetic Evolution & Animal Models, Sino-African Joint Research Center, and New Cornerstone Science Laboratory, National Resource Center for Non-Human Primates, Kunming Institute of Zoology, The Chinese Academy of Sciences, No.17 Longxin Road, Kunming, 650201, Yunnan, China.
Qiuyue XuDepartment of Clinical Laboratory, The First Affiliated Hospital of Kunming Medical University, Kunming, 650032, China.
Qiumin LuEngineering Laboratory of Peptides of Chinese Academy of Sciences, Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), State Key Laboratory of Genetic Evolution & Animal Models, Sino-African Joint Research Center, and New Cornerstone Science Laboratory, National Resource Center for Non-Human Primates, Kunming Institute of Zoology, The Chinese Academy of Sciences, No.17 Longxin Road, Kunming, 650201, Yunnan, China.
Ziyi WangEngineering Laboratory of Peptides of Chinese Academy of Sciences, Key Laboratory of Bioactive Peptides of Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, National Research Facility for Phenotypic & Genetic Analysis of Model Animals (Primate Facility), State Key Laboratory of Genetic Evolution & Animal Models, Sino-African Joint Research Center, and New Cornerstone Science Laboratory, National Resource Center for Non-Human Primates, Kunming Institute of Zoology, The Chinese Academy of Sciences, No.17 Longxin Road, Kunming, 650201, Yunnan, China.
Aili WangCenter for Evolution and Conservation Biology, Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou, 511458, China. allie612@gmlab.ac.cn.ORCID 0000-0002-8124-9697
Ren LaiCenter for Evolution and Conservation Biology, Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou, 511458, China. rlai@mail.kiz.ac.cn.

Funding

Guangxi Key Research and Development Program AB24010109Key-Area Research and Development Program of Guangdong Province 2023B1111050008Kunming Science and Technology Bureau 2022SCP007Postdoctoral Research Foundation of Guangzhou GML2023BH0915the Foundation for Scientific and Technical Project of Nansha, Guangzhou 2022ZD005the Guangdong Basic and Applied Basic Research Foundation 2023A1515110383the PI Project of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou) GML2021GD0807the Yunnan Characteristic Plant Extraction Laboratory 2025YKZY002Yunnan Provincial Science and Technology Department 202302AA310035Yunnan Provincial Science and Technology Department 202305AH340007
6 · The paper itself

Abstract

Stony corals (Scleractinia) harbor abundant toxins as part of their survival strategy, and these molecules also provide novel lead candidates for drug development. In this study, we present the first comprehensive investigation of toxin profiles of the understudied Goniopora columna through transcriptome analysis, which has expanded the biochemical diversity of marine organism derived toxins. Then, a novel Kunitz-like polypeptide, named GcKuz1, which exhibits therapeutic potential for thrombosis was selected for functional studies and mechanistic investigation. In vitro experiments revealed that GcKuz1, at 2-16 μM, delayed plasma recalcification time and activated partial thromboplastin time without affecting prothrombin time. In murine models, GcKuz1, at 1-4 mg/kg dosage, significantly inhibited the FeCl

Indexed as

AnthozoaPeptidesThrombosisAnimalsBlood-Brain BarrierBlood CoagulationDisease Models, AnimalHumansMaleMiceMice, Inbred C57BLPeptidesAnticoagulationContact-kinin PathwayKunitz peptideScleractiniaSerine protease inhibitors

Identifiers

PMID40464975

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.