ArticleInfectious diseases and therapy2025
Evaluating the Impact of Age and Comorbidities on COVID-19 Outcomes and Healthcare Costs: A Comparative Analysis of Immunocompromised and General Populations in the United States (EON-US).
Article in Infectious diseases and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Dysnatremia and Endocrine Alterations in Hospitalized COVID-19 Patients: Markers of Systemic Stress Rather than Independent Predictors of Outcomes.Biomedicines · 2026Article
- Hematological and biochemical markers for predicting severity in COVID-19 patients.BMC infectious diseases · 2026Observational
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe COVID-19 public health emergency (PHE) ended in May 2023, but limited information exists on the continued risk of severe COVID-19 among the immunocompromised (IC) population and those with certain chronic medical conditions (CMCs). This study aimed to assess the risk of moderate/severe COVID-19 and compare associated healthcare resource utilization (HCRU) and costs for IC vs. general populations, with a focus on increasing age and CMC burden in the IC population.
methodsThis retrospective observational cohort study analyzed claims from the Healthcare Integrated Research Database (HIRD
resultsThe IC cohort (N = 8025) was older and had a higher comorbidity burden than the general population (N = 458,163), which was balanced after matching (N = 7410 each). The IC cohort had a significantly higher rate of severe COVID-19 vs. the general population (9.5% vs. 1.1%; p < 0.001), but there was no difference after matching (8.9% vs. 8.7%; p = 0.772). Older age and increasing number of CMCs led to a significantly higher proportion of severe COVID-19. Compared to the general population, the IC cohort had significantly higher inpatient all-cause and COVID-19-related HCRU and costs, except within the matched analysis where COVID-19-related hospitalizations were not significantly different between the groups.
conclusionsSevere COVID-19 continued to disproportionately affect IC individuals after the PHE was lifted. Additionally, our matched results identified a subset of the general population with high baseline comorbidity burden and risk similar to the matched IC cohort for severe COVID-19.
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