Evidence map›Paper›PMID 40465331›Full record

ArticleChemistryOpen2025

Ibuprofen-Functionalized Alkyl α-hydroxy Methacrylate-Based Polymers.

Burcu Balaban, Seckin Altuncu, Aleyna Esenturk, Simay Denizkusu, Ece Sabuncu, Hande Sipahi, Duygu Avci

Abstract read
In one paragraph

Article in ChemistryOpen, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Burcu BalabanDepartment of Chemistry, Bogazici University, Bebek, 34342, Istanbul, Turkey.
Seckin AltuncuDepartment of Chemistry, Bogazici University, Bebek, 34342, Istanbul, Turkey.
Aleyna EsenturkDepartment of Chemistry, Bogazici University, Bebek, 34342, Istanbul, Turkey.
Simay DenizkusuDepartment of Chemistry, Bogazici University, Bebek, 34342, Istanbul, Turkey.
Ece SabuncuDepartment of Pharmaceutical Toxicology, Faculty of Pharmacy, Yeditepe University, Istanbul, 34775, Turkey.
Hande SipahiDepartment of Pharmaceutical Toxicology, Faculty of Pharmacy, Yeditepe University, Istanbul, 34775, Turkey.
Duygu AvciDepartment of Chemistry, Bogazici University, Bebek, 34342, Istanbul, Turkey.ORCID 0000-0002-9927-0291

Funding

Bogazici University BAP/ADP 50003
6 · The paper itself

Abstract

Novel alkyl α-hydroxymethacrylate-based prodrugs are prepared to improve bioavailability, decrease toxicity, and control drug release. First, an ibuprofen (IBU)-functionalized methacrylate (TBMA-IBU) is synthesized from the reaction of tert-butyl α-bromomethacrylate with IBU. The free radical homopolymerization and copolymerization with poly(ethylene glycol) methyl ether methacrylate (M

Indexed as

Anti-Inflammatory Agents, Non-SteroidalIbuprofenMethacrylatesPolymersProdrugsAnimalsCell SurvivalDrug LiberationMacrophagesMicePolyethylene GlycolsRAW 264.7 CellsAnti-Inflammatory Agents, Non-SteroidalIbuprofenMethacrylatesPolyethylene GlycolsPolymersProdrugsalkyl α‐hydroxymethacrylatesdrug designibuprofeninflammationpolymer‐drug conjugates

Identifiers

PMID40465331
PMCPMC12409833

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.