Evidence map›Paper›PMID 40466235›Full record

ArticleJournal of magnetic resonance (San Diego, Calif. : 1997)2025

Probing rare and short-lived conformational states in nucleic acids using off-resonance carbonyl and guanidino carbon R

Supriya Pratihar, Yeongjoon Lee, Ainan Geng, Shibani Bhattacharya, Hashim M Al-Hashimi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of magnetic resonance (San Diego, Calif. : 1997), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Supriya PratiharDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA.
Yeongjoon LeeDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA.
Ainan GengDepartment of Biochemistry, Duke University School of Medicine, Durham, NC 27710, USA.
Shibani BhattacharyaNew York Structural Biology Center, New York, NY, 10032, USA, 10027.
Hashim M Al-HashimiDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA. Electronic address: ha2639@cumc.columbia.edu.

Funding

The Center for HIV RNA Studies (CRNA)P50GM103297 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAYIE, KWAKU · 2012 to 2016
$21.7M
RM1 Center on Macromolecular Dynamics by NMR Spectroscopy at the New York Structural Biology Center (CoMD/NMR)- Equipment Supplement RequestRM1GM145397 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI ARTHUR G PALMER · 2022 to 2026
$8.3M
Role of DNA structural dynamics in mutagenesis and oncogenesisR01GM089846 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Hashim M Al-Hashimi · 2010 to 2026
$5.2M
NIGMS NIH HHS P50 GM103297NIGMS NIH HHS R01 GM089846NIGMS NIH HHS RM1 GM145397
6 · The paper itself

Abstract

Chemical exchange-based NMR techniques provide powerful approaches for characterizing lowly-populated and short-lived conformational states in nucleic acids. Among possible probes, the nucleobase carbonyl and guanidino carbons stand out due to the sensitivity of their chemical shifts to hydrogen bonding and keto-enol tautomerization. However, chemical exchange measurements targeting these carbon nuclei have not yet been reported in studies of nucleic acids. Here, we present an experiment for measuring off-resonance R

Indexed as

Nuclear Magnetic Resonance, BiomolecularNucleic Acid ConformationNucleic AcidsCarbonCarbon IsotopesDNAGuanineHydrogen BondingMagnetic Resonance SpectroscopyNitrogen IsotopesThymineUracilCarbonCarbon IsotopesDNAGuanineNitrogen IsotopesNucleic AcidsThymineUracilChemical exchangeDNADynamicsEnolMismatchRNATautomer

Identifiers

PMID40466235
PMCPMC13134533

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.