Evidence map›Paper›PMID 40466484›Full record

ArticleVaccine2025

Recombinant BCGΔBCG1419c protects outbred mice against M. tuberculosis challenge.

Sherry L Kurtz, Victoria Gould, Mario A Flores-Valdez, Karen L Elkins

Erratum issuedAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Vaccine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Fifteen years of the Diversity Outbred mouse model: a review.Mammalian genome : official journal of the International Mammalian Genome Society · 2026
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Sherry L KurtzCenter for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA. Electronic address: sherry.kurtz@fda.hhs.gov.
Victoria GouldCenter for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA.
Mario A Flores-ValdezBiotecnología Médica y Farmacéutica, Centro de Investigación y Asistencia en Tecnología y diseño del Estado de Jalisco, Av. Normalistas 800, Col. Colinas de la Normal, 44270 Guadalajara, Jalisco, Mexico.
Karen L ElkinsCenter for Biologics Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA. Electronic address: karen.elkins@fda.hhs.gov.

Funding

Systems Genetics of TuberculosisP01AI181898 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SAMUEL M BEHAR · 2024 to 2026
$10.5M
Intramural FDA HHS FD999999NIAID NIH HHS P01 AI181898
6 · The paper itself

Abstract

Mycobacterium tuberculosis remains a global health threat despite the world-wise use of the vaccine Bacille Calmette Guerin (BCG). Introducing a new vaccine could help to combat this pandemic, and efforts are underway to develop novel candidates, including by modifying parental BCG. Here, we use the genetically and phenotypically heterogenous Diversity Outbred mice to test the efficacy of the novel vaccine candidate BCGΔBCG1419c. BCGΔBCG1419c contains a mutation in BCG1419c, a phosphodiesterase linked with biofilm formation. BCGΔBCG1419c was previously shown to be more attenuated than the parental BCG strain in inbred mice and to provide protection against aerogenic M. tuberculosis challenge in inbred mice and guinea pigs. In the current study, we find that protection afforded by BCGΔBCG1419c in outbred DO mice is at least equivalent to, if not better than, that provided by parental BCG.

Indexed as

BCG VaccineMycobacterium tuberculosisTuberculosisAnimalsAnimals, Outbred StrainsDisease Models, AnimalFemaleMiceMycobacterium bovisVaccines, AttenuatedVaccines, SyntheticBCG VaccineVaccines, AttenuatedVaccines, SyntheticBCGBCGΔBCG1419cDO miceMycobacterium tuberculosisVaccination

Identifiers

PMID40466484
PMCPMC12354224

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.