Evidence map›Paper›PMID 40466645›Full record

ArticleCurrent biology : CB2025

Balanced synapse-to-synapse short-term plasticity ensures constant transmitter release.

Krisha Aghi, Ryan Schultz, R Steven Stowers, William YuChen Liu, Philipe R F Mendonça, Rachel Li, Dariya Bakshinska, Zachary L Newman, Ehud Y Isacoff

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current biology : CB, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Krisha AghiHelen Wills Neuroscience Institute, UC Berkeley, Berkeley, CA 94720, USA.
Ryan SchultzHelen Wills Neuroscience Institute, UC Berkeley, Berkeley, CA 94720, USA.
R Steven StowersDepartment of Microbiology & Cell Biology, Montana State University, PO Box 173520, Bozeman, MT 59717, USA.
William YuChen LiuHelen Wills Neuroscience Institute, UC Berkeley, Berkeley, CA 94720, USA; Department of Neuroscience, University of California Berkeley, Berkeley, CA 94720, USA.
Philipe R F MendonçaDepartment of Molecular and Cellular Biology, UC Berkeley, Berkeley, CA 94720, USA.
Rachel LiDepartment of Molecular and Cellular Biology, UC Berkeley, Berkeley, CA 94720, USA.
Dariya BakshinskaHelen Wills Neuroscience Institute, UC Berkeley, Berkeley, CA 94720, USA.
Zachary L NewmanDepartment of Molecular and Cellular Biology, UC Berkeley, Berkeley, CA 94720, USA.
Ehud Y IsacoffHelen Wills Neuroscience Institute, UC Berkeley, Berkeley, CA 94720, USA; Department of Neuroscience, University of California Berkeley, Berkeley, CA 94720, USA; Department of Molecular and Cellular Biology, UC Berkeley, Berkeley, CA 94720, USA; Molecular Biophysics and Integrated BioImaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA. Electronic address: ehud@berkeley.edu.

Funding

UPLIFT: UCLA Postdocs' Longitudinal Investment in Faculty TrainingK12GM106996 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CAREY, MICHAEL F, VILLANUEVA, CLAUDIO J · 2016 to 2025
$7.1M
Functional role of dual neurotransmitter usage in aggressionR01GM115510 · NIGMS · MONTANA STATE UNIVERSITY - BOZEMAN · PI Sarah J Certel, Karla R. Kaun · 2015 to 2026
$3.1M
Conformational mechanisms of mGluR gating and regulationR01NS119826 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI ISACOFF, EHUD · 2021 to 2024
$1.6M
Synaptic to circuit homeostasis in the Drosophila locomotor systemR01NS107506 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI ISACOFF, EHUD · 2019 to 2023
$1.6M
Upgrade for time-correlated single photon counting fluorescence lifetime laser scanning confocal microscopeS10OD025063 · OD · UNIVERSITY OF CALIFORNIA BERKELEY · PI AARON, HOLLY L · 2019 to 2019
$862k
NIGMS NIH HHS K12 GM106996NIGMS NIH HHS R01 GM115510NIH HHS S10 OD025063NINDS NIH HHS R01 NS107506NINDS NIH HHS R01 NS119826
6 · The paper itself

Abstract

Synaptic strength can vary greatly between synapses. Optical quantal analysis at Drosophila glutamatergic motor neuron synapses shows that short-term plasticity also varies greatly between synapses, even those made by an individual motor neuron. Strong and weak synapses are randomly distributed in the motor neuron nerve terminal, as are facilitating and depressing synapses. Although synapses exhibit highly heterogeneous basal strength at low-action potential firing frequency and undergo varied plasticity when firing frequency increases, the overall distribution of strength across synapses remains remarkably constant due to a balance between the number of synapses that facilitate versus depress and to their degree of plasticity and basal synaptic weight. Constancy in transmitter release can ensure robustness across changing behavioral conditions.

Indexed as

DrosophilaDrosophila melanogasterMotor NeuronsNeuronal PlasticityNeurotransmitter AgentsSynapsesSynaptic TransmissionAnimalsNeurotransmitter Agentsbiological stochasticityDrosophilaglutamatergicmotor neuronneuromuscularplasticityquantal analysissynapsesynaptic transmission

Identifiers

PMID40466645
PMCPMC12439520

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.