ArticleEndocrine journal2025
Single bolus injection of nicotinamide mono nucleotide increases systemic insulin sensitivity in association with activation of NAD salvage pathway in the liver and adipose tissue in mice.
Shunsuke Hiroshige, Yasuko Kajimura, Yuko Nagao, Akihiko Taguchi, Ryoko Hatanaka, Chika Yodokawa, Yuka Fujioka, Masaru Akiyama, Yukio Tanizawa, Yasuharu Ohta
Abstract read
In one paragraphArticle in Endocrine journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
10 authors.
Shunsuke HiroshigeDivision of Endocrinology, Metabolism, Hematological Science and Therapeutics, Department of Bio-Signal Analysis, Yamaguchi University, Graduate School of Medicine, Yamaguchi 755-8505, Japan.
Yasuko KajimuraDivision of Endocrinology, Metabolism, Hematological Science and Therapeutics, Department of Bio-Signal Analysis, Yamaguchi University, Graduate School of Medicine, Yamaguchi 755-8505, Japan.ORCID http://orcid.org/0000-0002-0819-6904 Yuko NagaoDivision of Endocrinology, Metabolism, Hematological Science and Therapeutics, Department of Bio-Signal Analysis, Yamaguchi University, Graduate School of Medicine, Yamaguchi 755-8505, Japan.ORCID http://orcid.org/0009-0000-8771-2243 Akihiko TaguchiDivision of Endocrinology, Metabolism, Hematological Science and Therapeutics, Department of Bio-Signal Analysis, Yamaguchi University, Graduate School of Medicine, Yamaguchi 755-8505, Japan.ORCID http://orcid.org/0000-0001-8544-5698 Ryoko HatanakaDivision of Endocrinology, Metabolism, Hematological Science and Therapeutics, Department of Bio-Signal Analysis, Yamaguchi University, Graduate School of Medicine, Yamaguchi 755-8505, Japan.
Chika YodokawaDivision of Endocrinology, Metabolism, Hematological Science and Therapeutics, Department of Bio-Signal Analysis, Yamaguchi University, Graduate School of Medicine, Yamaguchi 755-8505, Japan.
Yuka FujiokaDivision of Endocrinology, Metabolism, Hematological Science and Therapeutics, Department of Bio-Signal Analysis, Yamaguchi University, Graduate School of Medicine, Yamaguchi 755-8505, Japan.
Masaru AkiyamaDivision of Endocrinology, Metabolism, Hematological Science and Therapeutics, Department of Bio-Signal Analysis, Yamaguchi University, Graduate School of Medicine, Yamaguchi 755-8505, Japan.
Yukio TanizawaDivision of Endocrinology, Metabolism, Hematological Science and Therapeutics, Department of Bio-Signal Analysis, Yamaguchi University, Graduate School of Medicine, Yamaguchi 755-8505, Japan.ORCID http://orcid.org/0000-0002-4742-8245 Yasuharu OhtaDivision of Endocrinology, Metabolism, Hematological Science and Therapeutics, Department of Bio-Signal Analysis, Yamaguchi University, Graduate School of Medicine, Yamaguchi 755-8505, Japan.ORCID http://orcid.org/0000-0002-9117-6874 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Rising nicotinamide adenine dinucleotide (NAD
Indexed as
Adipose TissueInsulin ResistanceLiverNADNicotinamide MononucleotideAnimalsCytokinesFatty Acids, NonesterifiedGlucose Tolerance TestInsulinMaleMiceMice, Inbred C57BLMuscle, SkeletalNicotinamide PhosphoribosyltransferaseSirtuin 1CytokinesFatty Acids, NonesterifiedInsulinNADNicotinamide MononucleotideNicotinamide Phosphoribosyltransferasenicotinamide phosphoribosyltransferase, mouseSirt1 protein, mouseSirtuin 1Insulin sensitivityLipid metabolismNAD+NMNSingle bolus injection
Identifiers
PMID40467473
PMCPMC12436074
What Socratic holds
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