Evidence map›Paper›PMID 40467577›Full record

ArticleTranslational psychiatry2025

Cerebral perfusion is correlated with cerebral metabolism and amyloid deposition in Alzheimer's disease.

Ping Che, Li Cai, Fang Liu, Yidi Wang, Yanxin Zhang, Ying Wang, Qingzheng Lu, Zhiyan Piao, Xiaoyi Zhang, Wen Qin and 1 more

Abstract read
In one paragraph

Article in Translational psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ping Che *Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China.
Li Cai *PET/CT Center, Tianjin Medical University General Hospital, Tianjin, China.
Fang LiuDepartment of Neurology, Yulin First Hospital, Yulin City, Shanxi Province, China.
Yidi WangDepartment of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China.
Yanxin ZhangDepartment of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China.
Ying WangPET/CT Center, Tianjin Medical University General Hospital, Tianjin, China.
Qingzheng LuDepartment of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China.
Zhiyan PiaoDepartment of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China.
Xiaoyi ZhangDepartment of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China.
Wen QinDepartment of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin, China.
Nan ZhangDepartment of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China. nkzhangnan@yeah.net.ORCID http://orcid.org/0000-0002-9675-5322

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cerebral blood flow (CBF) changes play a pivotal role in the pathogenesis and progression of Alzheimer's disease (AD), but their effects on other pathological processes, such as neurodegeneration and amyloid-β deposition, are unclear. We investigated the correlations between cerebral perfusion measured with arterial spinal labeling (ASL) and cerebral metabolism and amyloid deposition on positron emission tomography (PET) scans in AD. Sixty-four AD patients and 56 cognitively unimpaired controls were included. Cerebral perfusion was indicated by the expression of AD-related perfusion pattern (ADRP), global CBF and the relative value of regional CBF. The standardized uptake value ratio (SUVR) of regions of interest (ROIs) was calculated for

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesBrainCerebrovascular CirculationAgedAged, 80 and overAniline CompoundsCase-Control StudiesFemaleFluorodeoxyglucose F18HumansMaleMiddle AgedPositron-Emission TomographyRadiopharmaceuticalsThiazoles2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazoleAmyloid beta-PeptidesAniline CompoundsFluorodeoxyglucose F18RadiopharmaceuticalsThiazoles

Identifiers

PMID40467577
PMCPMC12137571

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.