Evidence mapPaperPMID 40467749Full record

ArticleScientific reports2025

Keratin 80 as a diagnostic biomarker with limited prognostic value in non-small cell lung cancer.

Ying Zeng, Hongting Jiang, Yuting Xia, Zhonglian Wang, Fei Zhang, Cha Luo, Qing Ye, Wei Jian, Jing Zhang, Qingmei Yang and 1 more

Abstract read
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ying Zeng *Department of Radiation Oncology, The First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, Yunnan, China.
Hongting Jiang *Department of Radiation Oncology, The First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, Yunnan, China.
Yuting XiaDepartments of Cancer Biotherapy Center, The Third Affiliated Hospital of Kunming Medical University (Tumor Hospital of Yunnan Province), Kunming, Yunnan, China.
Zhonglian WangDepartment of Radiation Oncology, The First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, Yunnan, China.
Fei ZhangDepartment of Radiation Oncology, The First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, Yunnan, China.
Cha LuoDepartment of Radiation Oncology, The First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, Yunnan, China.
Qing YeDepartment of Radiation Oncology, The First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, Yunnan, China.
Wei JianDepartment of Radiation Oncology, The First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, Yunnan, China.
Jing ZhangDepartment of Radiation Oncology, The First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, Yunnan, China.
Qingmei YangSecond Department of Thoracic Surgery, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China.
Qiaofen FuDepartment of Radiation Oncology, The First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, Yunnan, China. fuqiaofen@163.com.

Funding

Kunming Medical University Graduate Student Innovation Fund Project 2024S059the 535 Talent Project of the First Affiliated Hospital of Kunming Medical University No. 2023535D17the Joint Fund of the Department of Science and Technology of Yunnan Province No. 202001AY070001-141the National Natural Science Foundation of China No. 82160529the Yunnan Revitalization Talent Support Program grant no. RLQB20220014
6 · The paper itself

Abstract

To investigate the expression of KRT80 in non-small cell lung cancer (NSCLC) patients and its relationship with clinicopathological factors, prognosis, as well as the differences in KRT80 expression between Xuanwei area and Non-xuanwei area, lung adenocarcinoma and lung squamous cell carcinoma. Based on 178 clinical cases, immunohistochemical methods combined with public databases were used to examine the expression of KRT80 in NSCLC patients and analyze its correlation with various clinicopathological factors and prognosis. The study confirmed the up-regulation of KRT80 expression in NSCLC cancer tissues. Significant regional specific and histological subtype differences in KRT80 expression were revealed. Although the expression level of KRT80 has no direct significant correlation with the prognosis of NSCLC patients, it has a good ability to distinguish cancerous tissue from paracancer tissue. KRT80 can be used as a diagnostic biomarker for NSCLC patients, but its specific mechanism and clinical application value still need to be further explored.

Indexed as

Carcinoma, Non-Small-Cell LungKeratins, Type IILung NeoplasmsAdultAgedBiomarkers, TumorChinaFemaleHumansImmunohistochemistryMaleMiddle AgedBiomarkers, TumorKeratins, Type IIKRT80 protein, humanBiomarkersKRT80NSCLCXuanwei lung cancer

Identifiers

PMID40467749
PMCPMC12137948

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.