Evidence map›Paper›PMID 40468041›Full record

ArticleNature ecology & evolution2025

Climate warming fuels the global antibiotic resistome by altering soil bacterial traits.

Da Lin, Shuai Du, Zhe Zhao, Tianlun Zhang, Lu Wang, Qi Zhang, Shu-Yi-Dan Zhou, David W Graham, David T Tissue, Dong Zhu and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature ecology & evolution, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Antimicrobial Resistance Under a Changing Climate.Journal of the Royal Society of New Zealand · 2026
    Article
  2. Article
  3. Article
  4. Impacts of pollution on the soil microbiome.Nature reviews. Microbiology · 2026
    Review
  5. Temperature-Associated Prevalence and Multidrug Resistance ofAnimals : an open access journal from MDPI · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Phages drive the dissemination of antibiotic resistance genes by facilitating host adaptation to heavy metal stress.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
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  19. Article
  20. Nano-biochar regulates phage-host interactions, reducing antibiotic resistance genes in vermicomposting systems.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Da Lin *State Key Laboratory of Regional and Urban Ecology, Ningbo Observation and Research Station, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, China.
Shuai Du *State Key Laboratory of Regional and Urban Ecology, Ningbo Observation and Research Station, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, China.
Zhe ZhaoState Key Laboratory of Urban and Regional Ecology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.ORCID http://orcid.org/0000-0002-3680-0654
Tianlun ZhangState Key Laboratory of Regional and Urban Ecology, Ningbo Observation and Research Station, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, China.
Lu WangState Key Laboratory of Regional and Urban Ecology, Ningbo Observation and Research Station, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, China.
Qi ZhangCollege of Chemistry and Chemical Engineering, Shaoxing University, Shaoxing, China.
Shu-Yi-Dan ZhouGuangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, China. sydzhou@scbg.ac.cn.ORCID http://orcid.org/0000-0002-2585-7305
David W GrahamDepartment of Biosciences, Durham University, Durham, UK.ORCID http://orcid.org/0000-0002-9753-496X
David T TissueHawkesbury Institute for the Environment, Western Sydney University, Richmond, Australia.ORCID http://orcid.org/0000-0002-8497-2047
Dong ZhuState Key Laboratory of Regional and Urban Ecology, Ningbo Observation and Research Station, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, China. dzhu@iue.ac.cn.ORCID http://orcid.org/0000-0002-0826-6423
Yong-Guan ZhuState Key Laboratory of Regional and Urban Ecology, Ningbo Observation and Research Station, Institute of Urban Environment, Chinese Academy of Sciences, Xiamen, China.ORCID http://orcid.org/0000-0003-3861-8482
Josep PenuelasGlobal Ecology Unit CREAF-CSIC-UAB, CSIC, Barcelona, Spain.ORCID http://orcid.org/0000-0002-7215-0150
Peter B ReichInstitute for Global Change Biology and School for Environment and Sustainability, University of Michigan, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0003-4424-662X

Funding

National Natural Science Foundation of China (National Science Foundation of China) 42090063National Natural Science Foundation of China (National Science Foundation of China) 42222701Youth Innovation Promotion Association of the Chinese Academy of Sciences (Youth Innovation Promotion Association CAS) 2023321
6 · The paper itself

Abstract

Understanding the implications of global warming on the spread of antibiotic resistance genes (ARGs) and virulence factor genes (VFGs) within soil ecosystems is crucial for safeguarding human well-being and sustaining ecosystem health. However, there is currently a lack of large-scale, systematic underpinning data needed to examine this issue. Here, using an integrative approach that combines field experiments, extensive global metagenomic data and microbial culturing, we show that warming enriches bacteria with ARGs and VFGs, increases metabolic complexity and adaptability in bacteria, and accelerates genetic alterations related to ARG and VFGs development. Our validation experiments confirm that the warming effect is more pronounced in colder regions. Machine learning predictions further suggest that warming will increase the soil ARG abundance, especially in some areas that rely heavily on fossil fuels. These results suggest another major negative consequence of global warming, highlighting the importance of developing and implementing sustainability policies that simultaneously combat climate change and antibiotic resistance.

Indexed as

BacteriaDrug Resistance, BacterialDrug Resistance, MicrobialGlobal WarmingSoil MicrobiologyAnti-Bacterial AgentsClimate ChangeGenes, BacterialVirulence FactorsAnti-Bacterial AgentsVirulence Factors

Identifiers

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.