Evidence map›Paper›PMID 40468363›Full record

ArticleJournal of translational medicine2025

A novel mechanism of radiation-induced lung injury: METTL3 mediates fibrogenesis through N6-methyladenosine modification of YY1.

Weiqiang Xu, Junxuan Yi, Xinfeng Wei, Mingwei Wang, Mingqi Zhao, Mengdie Zhao, Xinyan Wang, Yannan Shen, Zhicheng Wang, Shunzi Jin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of translational medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Murine models of pulmonary fibrosis: mechanisms, limitations and translational insights.European respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  2. Review
  3. The Emerging Role of METTL3 in Lung Diseases.International journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Weiqiang XuNHC Key Laboratory of Radiobiology, School of Public Health, Jilin University, Changchun, Jilin, 130021, China.
Junxuan YiNHC Key Laboratory of Radiobiology, School of Public Health, Jilin University, Changchun, Jilin, 130021, China.
Xinfeng WeiNHC Key Laboratory of Radiobiology, School of Public Health, Jilin University, Changchun, Jilin, 130021, China.
Mingwei WangNHC Key Laboratory of Radiobiology, School of Public Health, Jilin University, Changchun, Jilin, 130021, China.
Mingqi ZhaoNHC Key Laboratory of Radiobiology, School of Public Health, Jilin University, Changchun, Jilin, 130021, China.
Mengdie ZhaoNHC Key Laboratory of Radiobiology, School of Public Health, Jilin University, Changchun, Jilin, 130021, China.
Xinyan WangNHC Key Laboratory of Radiobiology, School of Public Health, Jilin University, Changchun, Jilin, 130021, China.
Yannan ShenNHC Key Laboratory of Radiobiology, School of Public Health, Jilin University, Changchun, Jilin, 130021, China.
Zhicheng WangNHC Key Laboratory of Radiobiology, School of Public Health, Jilin University, Changchun, Jilin, 130021, China. zhicheng@jlu.edu.cn.
Shunzi JinNHC Key Laboratory of Radiobiology, School of Public Health, Jilin University, Changchun, Jilin, 130021, China. jinsz@jlu.edu.cn.

Funding

National Natural Science Foundation of China No.82173454the Science and Technology Development Plan of Jilin 20240101275JCthe Science and Technology Development Plan of Jilin YDZJ202401200ZYTS
6 · The paper itself

Abstract

backgroundN6-methyladenosine (m

methodsThe expression of METTL3 and YY1 were quantified in human lung fibroblasts and Radiation-Induced Lung Injury (RILI) mouse models. We systematically investigated whether METTL3 regulates YY1 expression through m

resultsMETTL3 was significantly upregulated at both transcriptional and translational levels in RILI mouse lungs and irradiated human lung fibroblasts. YY1 expression was mechanistically depended on METTL3-mediated m

conclusionOur data show that METTL3-mediated m

Indexed as

AdenosineLung InjuryMethyltransferasesYY1 Transcription FactorAnimalsFibroblastsFibrosisHumansLungMiceMice, Inbred C57BLRNA-Binding ProteinsRNA, MessengerRNA StabilityAdenosineIGF2BP1 protein, humanMethyltransferasesMETTL3 protein, humanMettl3 protein, mouseN-methyladenosineRNA-Binding ProteinsRNA, MessengerYY1 protein, humanYY1 Transcription Factor

Identifiers

PMID40468363
PMCPMC12139223

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.