Evidence map›Paper›PMID 40468378›Full record

ArticleActa neuropathologica communications2025

Lipid metabolism disorder promoting retinal structural and functional damage in ApoE

Rucui Yang, Shaolang Chen, Tsz Kin Ng, Jiajian Liang, Shaofen Huang, Minru Deng, Zhenggen Wu, Yaru Sun, Changzhen Fu, Chi Pui Pang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neuropathologica communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Rucui YangJoint Shantou International Eye Center of Shantou University, The Chinese University of Hong Kong, Shantou, Guangdong, China.
Shaolang ChenJoint Shantou International Eye Center of Shantou University, The Chinese University of Hong Kong, Shantou, Guangdong, China.
Tsz Kin NgJoint Shantou International Eye Center of Shantou University, The Chinese University of Hong Kong, Shantou, Guangdong, China.
Jiajian LiangJoint Shantou International Eye Center of Shantou University, The Chinese University of Hong Kong, Shantou, Guangdong, China.
Shaofen HuangJoint Shantou International Eye Center of Shantou University, The Chinese University of Hong Kong, Shantou, Guangdong, China.
Minru DengJoint Shantou International Eye Center of Shantou University, The Chinese University of Hong Kong, Shantou, Guangdong, China.
Zhenggen WuJoint Shantou International Eye Center of Shantou University, The Chinese University of Hong Kong, Shantou, Guangdong, China.
Yaru SunJoint Shantou International Eye Center of Shantou University, The Chinese University of Hong Kong, Shantou, Guangdong, China.
Changzhen FuJoint Shantou International Eye Center of Shantou University, The Chinese University of Hong Kong, Shantou, Guangdong, China.
Chi Pui PangJoint Shantou International Eye Center of Shantou University, The Chinese University of Hong Kong, Shantou, Guangdong, China.
Qingping LiuJoint Shantou International Eye Center of Shantou University, The Chinese University of Hong Kong, Shantou, Guangdong, China. lqp@jsiec.org.
Mingzhi ZhangJoint Shantou International Eye Center of Shantou University, The Chinese University of Hong Kong, Shantou, Guangdong, China. zmz@jsiec.org.

Funding

National Natural Science Foundation of China 82171044Natural Science Foundation of Guangdong Province 2022A1515011646Special Fund Project for Science and Technology Innovation Strategy of Guangdong Province 2019ST024
6 · The paper itself

Abstract

This study aimed to establish a model of abnormal lipid metabolism in Apolipoprotein E (ApoE) knockout mice by feeding them a high-fat diet (HFD) and to investigate the impact of this abnormal lipid metabolism on retinal blood perfusion, structure, and function, particularly the retinal ganglion cell (RGC). Both HFD and regular diet (RD) feeding were conducted in C57BL/6J mice and ApoE

Indexed as

AgingApolipoproteins ELipid MetabolismLipid Metabolism DisordersRetinaAnimalsDiet, High-FatDisease Models, AnimalElectroretinographyIntraocular PressureMaleMiceMice, Inbred C57BLMice, KnockoutMice, Knockout, ApoERetinal Ganglion CellsApolipoproteins EApoE −/− miceBlood perfusionHigh‑fat dietLipid metabolism disorderRetinaRGC damage

Identifiers

PMID40468378
PMCPMC12135408

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.