ArticleBMC sports science, medicine & rehabilitation2025
Relative effectiveness of different exercise interventions on cardiovascular events in individuals with prediabetes: a systematic review and network meta-analysis.
Article in BMC sports science, medicine & rehabilitation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Effectiveness of eHealth Interventions on Health Outcomes in Adult Patients With Intestinal Stoma: A Systematic Review and Network Meta-Analysis.International journal of nursing practice · 2026Pooled it
- Prediabetes and stroke risk in U.S. adults: a machine learning-based analysis with causal mediation insights.Diabetology & metabolic syndrome · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrediabetes significantly increases the risk of cardiovascular disease (CVD), including myocardial infarction, stroke, and cardiovascular death. However, the relative effectiveness of different types of exercise interventions in reducing CVD risk in this population is unclear. The aim of this systematic evaluation and network meta-analysis (NMA) was to compare the effectiveness of aerobic exercise (AE), resistance training (RT), mind-body training (MBT), and combined aerobic and resistance training (AE + RT) interventions on CVD events and their associated risk factors.
methodsRandomized controlled trials (RCTs) published up to May 2025 were systematically searched in PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure (CNKI), Wanfang Database, and VIP Database. Studies were required to report the effect of exercise interventions on cardiovascular event metrics such as Framingham score, 10-year CVD risk, and ICVD score. Two investigators independently completed screening, data extraction, and quality assessment. Network meta-analysis was performed using Stata 17.0, and intervention effects were ranked based on Surface Under the Cumulative Ranking (SUCRA) values.
resultsA total of 6 RCTs involving 1,265 subjects were included. The results showed that RT was the most effective in reducing cardiovascular risk, showing the lowest SUCRA values for Framingham score, ICVD score, and insulin resistance (HOMA2-IR). This effect was statistically significant. AE + RT had the most significant advantage in reducing glycated hemoglobin (HbA1c, SUCRA = 26.7%, 95% CI [0.02, 0.89]) and triglycerides (TG, SUCRA = 9.1%). MBT had the optimal effect in improving lipids, as evidenced by higher High-Density Lipoprotein Cholesterol (SUCRA = 85.3%, 95% CI [4.05, 56.83]) and lower Low-Density Lipoprotein Cholesterol, both of which were statistically significant. No significant publication bias or consistency issues were identified in this study.
conclusionDifferent types of exercise interventions have differentiated advantages on cardiovascular risk and metabolic outcomes in prediabetic populations. RT is more suitable for controlling blood glucose and insulin resistance, AE + RT has the best effect on improving dual indexes of blood glucose and blood lipids, and MBT has a prominent role in lipid regulation. Compared with the traditional Meta-analysis, this study is the first to evaluate the relative effects of multiple exercise interventions through a network meta-analysis, which can provide a scientific basis for developing individualized and risk-oriented exercise prescriptions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.