Evidence map›Paper›PMID 40468425›Full record

ArticleJournal of eating disorders2025

Interoceptive impairments in early-stage anorexia nervosa: exploring the impact of childhood trauma and heart rate variability.

Lorenzo Moccia, Cassandra Serantoni, Marianna Ambrosecchia, Eliana Conte, Giuseppe Maulucci, Delfina Janiri, Georgios D Kotzalidis, Vassilij Di Giorgio, Fabio Conti, Marco De Spirito and 2 more

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Article in Journal of eating disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Lorenzo Moccia *Department of Neuroscience, Section of Psychiatry, Università Cattolica del Sacro Cuore, Largo Francesco Vito 1, 00168, Rome, Italy. lorenzomoccia27@gmail.com.
Cassandra Serantoni *Department of Neuroscience, Section of Physics, Università Cattolica del Sacro Cuore, 00168, Rome, Italy.
Marianna AmbrosecchiaDepartment of Medicine and Surgery, Unit of Neuroscience, University of Parma, Via Volturno 39, 43121, Parma, Italy.
Eliana ConteDepartment of Neuroscience, Section of Psychiatry, Università Cattolica del Sacro Cuore, Largo Francesco Vito 1, 00168, Rome, Italy.
Giuseppe MaulucciDepartment of Neuroscience, Section of Physics, Università Cattolica del Sacro Cuore, 00168, Rome, Italy.
Delfina JaniriDepartment of Neuroscience, Section of Psychiatry, Università Cattolica del Sacro Cuore, Largo Francesco Vito 1, 00168, Rome, Italy.
Georgios D KotzalidisDepartment of Neuroscience, Section of Psychiatry, Università Cattolica del Sacro Cuore, Largo Francesco Vito 1, 00168, Rome, Italy.
Vassilij Di GiorgioIstituto Di Neuroscienze, Neomesia Kos Group, Via Nomentana 1362, 00137, Rome, Italy.
Fabio ContiIstituto Di Neuroscienze, Neomesia Kos Group, Via Nomentana 1362, 00137, Rome, Italy.
Marco De SpiritoDepartment of Neuroscience, Section of Physics, Università Cattolica del Sacro Cuore, 00168, Rome, Italy.
Vittorio Gallese *Department of Medicine and Surgery, Unit of Neuroscience, University of Parma, Via Volturno 39, 43121, Parma, Italy.
Gabriele Sani *Department of Neuroscience, Section of Psychiatry, Università Cattolica del Sacro Cuore, Largo Francesco Vito 1, 00168, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAnorexia nervosa, restricting subtype (AN-R), is a severe psychiatric disorder, with abnormal interoception, autonomic nervous system disturbances, and increased exposure to childhood traumatic experiences (CTEs), frequently observed as correlates. This is the first study exploring the impact of CTEs and heart rate variability (HRV; i.e., an index reflecting parasympathetic arousal) on interoceptive accuracy (IA; i.e., the ability to track changes in bodily signals) in AN.

methodsTwenty-five patients with AN-R within a year of onset and 25 matched healthy controls were recruited. IA was assessed through the heart beat detection task. HRV was measured before and after the task. Participants also completed the Childhood Trauma Questionnaire. We performed a to detect significant differences between groups in HRV reactivity and IA, and a linear regression to test the effect of factors of interest on IA.

resultsPatients with AN-R displayed significantly increased HRV reactivity and decreased IA compared to HCs. They also reported significantly more CTEs. Furthermore, childhood emotional neglect significantly predicts IA impairments.

conclusionsAlthough the pathway linking emotional neglect to abnormal interoception in AN-R remains to be clarified, an embodiment-informed framework may show promise in the treatment of individuals with eating disorders who experienced childhood maltreatment.

Indexed as

Anorexia NervosaChildhood abuseEarly adverse experiencesEating disordersInteroceptionRestrictive type

Identifiers

PMID40468425
PMCPMC12139314

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.