ArticleMolecular horticulture2025
Smi-miRmTERF regulates organelle development, retrograde signaling, secondary metabolism and immunity via targeting a subset of SmmTERFs in Salvia miltiorrhiza.
Article in Molecular horticulture, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Review
- Non-coding RNA: a new perspective on the regulation of secondary metabolites in medicinal plants.Molecular horticulture · 2026Review
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Authors and funding
10 authors.
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No grant is acknowledged in the PubMed record.
Abstract
MicroRNAs are a class of endogenous small non-coding RNAs, some of which can trigger phased secondary small interfering RNA (phasiRNA) production from target genes. Mitochondrial transcription termination factors (mTERFs), mainly localized in chloroplasts and/or mitochondria, play critical roles in plant development and stress responses. We report here the identification of 63 mTERFs and a 22 nt novel miRNA (smi-miRmTERF), which directly cleave SmmTERF33 and SmmTERF45 transcripts to trigger phasiRNA biogenesis. The generated phasiRNAs could further trigger phasiRNA biogenesis from SmmTERF26 and regulated a subset of lineage-specific SmmTERFs. MIRmTERF widely existed in Nepetoideae plants and SmmTERF33 and SmmTERF45 proteins were localized in chloroplasts, mitochondria, and the cytoplasm. Smi-miRmTERF overexpression (MIRMTERF#OE) resulted in a dwarfing phenotype with severe defects in chloroplast and mitochondrial morphogenesis. Transcriptomic analysis showed up-regulation of defense-related and down-regulation of photosynthesis-related genes in MIRMTERF#OE plants. Under norflurazon and lincomycin treatments, MIRMTERF#OE plants displayed a gun phenotype, indicating the role of smi-miRmTERF in retrograde signaling. Furthermore, MIRMTERF#OE plants showed increased contents of phenolic acids, monoterpenoids, and sesquiterpenoids and reduced susceptibility to pathogenic bacteria Pst DC3000. The results suggest that smi-miRmTERF is a significant regulator of chloroplast and mitochondrial development, retrograde signaling, secondary metabolism, and immunity in S. miltiorrhiza.
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Registered trials
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