Evidence map›Paper›PMID 40468530›Full record

ArticleUnited European gastroenterology journal2025

Key Predictors of Relevant Weight Loss in Patients With Metabolic Dysfunction-Associated Steatotic Liver Disease.

Nicola Pugliese, Ivan Arcari, Federica Cerini, Rosa Lombardi, Federica Turati, Grazia Pennisi, Matteo Soleri, Simone Rocchetto, Diletta De Deo, Michele Sagasta and 6 more

Abstract readMulticenter Study
In one paragraph

Article in United European gastroenterology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Focus on Semaglutide 2.4 mg/week for the Treatment of Metabolic Dysfunction-Associated Steatohepatitis.Liver international : official journal of the International Association for the Study of the Liver · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Nicola PuglieseDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.
Ivan ArcariDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.
Federica CeriniHepatology Unit, San Giuseppe Hospital, Milan, Italy.
Rosa LombardiUnit of Metabolic Disease, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy.ORCID https://orcid.org/0000-0001-6958-927X
Federica TuratiDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Grazia PennisiSection of Gastroenterology, PROMISE, University of Palermo, Palermo, Italy.
Matteo SoleriDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.
Simone RocchettoHepatology Unit, San Giuseppe Hospital, Milan, Italy.
Diletta De DeoDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.
Michele SagastaDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.
Chiara MasettiDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.
Anna Ludovica FracanzaniUnit of Metabolic Disease, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico di Milano, Milan, Italy.
Salvatore PettaSection of Gastroenterology, PROMISE, University of Palermo, Palermo, Italy.ORCID https://orcid.org/0000-0002-0822-9673
Carlo La VecchiaDepartment of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Mauro ViganòGastroenterology, Hepatology and Transplantation Unit, ASST Papa Giovanni XXIII, Bergamo, Italy.
Alessio AghemoDepartment of Biomedical Sciences, Humanitas University, Pieve Emanuele, Italy.

Funding

Heal Italia project PE00000019 CUP B73C22001250006Italian PNRR-MAD-2022-12375656Ministero dell'Istruzione, dell'Università e della Ricerca PNRR M4C2I1.3PRIN 2022 2022L273C9RF-2021-12372399
6 · The paper itself

Abstract

BACKGROUND AND

aimsWeight loss is an effective therapeutic strategy for patients with metabolic dysfunction-associated steatotic liver disease (MASLD). This study aimed to identify factors that predict relevant weight loss, defined as at least 7% of initial body weight, in MASLD outpatients.

methodWe retrospectively included all MASLD patients referred to four Italian tertiary centers between January 2019 and December 2021. Patients received lifestyle modification advice according to current guidelines, with reassessment of anthropometric measures after 18-24 months.

resultsA total of 897 patients were included. The majority were male (57%) with a mean age of 61.6 ± 13.3 years and a mean baseline body mass index (BMI) of 30.3 ± 4.5 kg/m

conclusionsBaseline BMI ≥ 30 kg/m

Indexed as

Fatty LiverWeight LossAgedBilirubinBody Mass IndexComorbidityDiabetes Mellitus, Type 2FemaleHumansItalyMaleMiddle AgedRetrospective StudiesBilirubindietexerciseGLP‐1 agonistslifestyle modificationMASLDmetabolic syndromeobesitysteatotic liver diseasetype 2 diabetesweight loss

Identifiers

PMID40468530
PMCPMC12463688

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.