ArticleMagnetic resonance in medicine2025
Diffusion MRI in the cortex of the brain: Reducing partial volume effects from CSF and white matter in the mean diffusivity using high b-values and spherical b-tensor encoding.
Article in Magnetic resonance in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Microstructure imaging in patients undergoing evaluation for epilepsy surgery or low-grade glioma: Clinical utility of a novel diffusion MRI method.Epilepsia open · 2026Article
- Diffusion MRI in the cortex of the brain: Reducing partial volume effects from CSF and white matter in the mean diffusivity using high b-values and spherical b-tensor encoding.Magnetic resonance in medicine · 2025Article
- Auxiliary Value of [Cancers · 2025Article
- Mean Diffusivity of the Left Caudal Anterior Cingulate Cortex and Past Major Depressive Disorder in Adolescents: Evidence from the ABCD Study.Journal of cellular neuroscience · 2025Article
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Authors and funding
7 authors.
Funding
Abstract
purposeThe mean diffusivity (MD) is sensitive to the microstructure of the cortex. However, partial volume effects with CSF and white matter (WM) may obscure pathology-related alterations. This work investigates both existing approaches and a novel approach for reducing partial volume effects. THEORY AND
methodsA bias in MD arises due to partial volume effects, higher-order terms, and the noise floor in magnitude data. We propose to reduce this bias by using high b-value encoding to limit partial volume effects with CSF, spherical b-tensor encoding to reduce the influence of higher-order terms, and super-resolution acquisition and reconstruction to suppress the noise floor. This approach was investigated, along with established approaches (inversion recovery and free water elimination) for reducing partial volume effects, using simulations and in vivo data.
resultsHigh b-value diffusion MRI with spherical b-tensor encoding reduced partial volume effects with CSF relative to conventional diffusion MRI. Maximum errors decreased from 0.51 to 0.01 μm
conclusionThe mean diffusivity of the cortex can be mapped in high precision with reduced influence of partial volume effects with CSF and WM matter using high b-values and spherical b-tensor encoding and super-resolution reconstruction.
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