ArticleThe Journal of small animal practice2025
Glomerular ultrastructural change and vascular endothelial growth factor-A expression in diabetic cats.
Article in The Journal of small animal practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- 2026 iCatCare consensus guidelines on the diagnosis and management of chronic kidney disease in cats.Journal of feline medicine and surgery · 2026Guideline
- Mitochondria-associated endoplasmic reticulum membranes in canine and feline diabetic kidney disease: mechanistic links and nutritional implications.Frontiers in veterinary science · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
objectivesTo evaluate the glomerular ultrastructural changes associated with diabetic nephropathy and quantify glomerular vascular endothelial growth factor-A expression in cats with diabetes mellitus compared to controls. MATERIALS AND
methodsTransmission electron microscopy was performed to evaluate glomerular ultrastructural changes, including glomerular endothelial cell fenestration density and width, glomerular basement membrane width, podocyte foot process width, and podocyte slit width and density in four diabetic and five control cats. Glomerular vascular endothelial growth factor-A expression was quantified using immunohistochemistry in eight diabetic and five control cats.
resultsGlomerular ultrastructural change consistent with diabetic nephropathy, including loss of glomerular endothelial cell fenestrations and thickened glomerular basement membrane, was present in diabetic cats. Furthermore, diabetic cats had increased glomerular vascular endothelial growth factor-A expression. CLINICAL SIGNIFICANCE: This study demonstrates that diabetic nephropathy may develop in diabetic cats, which although representing early subclinical disease, may contribute to decreased glomerular filtering capacity and proteinuria and therefore requires clinical monitoring.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.