Evidence mapPaperPMID 40468684Full record

Trial reportJournal of the International Society of Sports Nutrition2025

Effect of different sports drink compositions on endurance performance and substrate oxidation: a randomized, double-blind, placebo-controlled crossover study in trained athletes.

Sascha Ketelhut, Martin Moehle, Laura Hottenrott

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of the International Society of Sports Nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sascha KetelhutUniversity of Bern, Institute of Sport Science, Bern, Switzerland.ORCID 0000-0002-6875-9625
Martin MoehleMartin-Luther-University Halle-Wittenberg, Institute of Sport Science, Halle (Saale), Germany.
Laura HottenrottMartin-Luther-University of Halle-Wittenberg, Institute for Performance Diagnostics and Health Promotion, Halle (Saale), Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe consumption of sports drinks before, during, and after endurance exercise is a common practice among athletes. These drinks typically contain a variety of components, each of which has been shown to offer individual benefits. However, the combined effects of these components, as formulated in many sports drinks, have not been thoroughly investigated. This study aims to evaluate the impact of typical sports drink components on endurance performance, perceived exertion, and carbohydrate and fat metabolism, using a sequential additive design.

methodsTwelve healthy, trained endurance athletes aged 20 to 35 years participated in a randomized, double-blind, placebo-controlled study. The study involved a baseline assessment and four exercise protocols, each separated by a 7-day washout period. During each exercise protocol, participants cycled for 40 minutes at 80% of their previously determined peak oxygen uptake , followed by an incremental protocol performed to voluntary exhaustion. Participants were randomly assigned to ingest one of four 300 ml solutions 60 and 30 minutes before each exercise protocol: solution A (placebo mineral water), solution B (dextrose and sodium), solution C (solution B + beetroot extract), or solution D (solution C + arginine and L-citrulline). Ventilation and heart rate were continuously monitored before and throughout the exercise. Lactate and glucose levels were measured at specific time points before and during the exercise, while ratings of perceived exertion were recorded every 10 minutes. Power output was continuously tracked throughout the exercise protocol. Body weight was assessed both before and after each exercise session.

resultsThere were no significant differences between the four solutions in terms of time to exhaustion (

conclusionsThe effect of the tested sports drink compositions on performance during the selected exercise protocol to voluntary exhaustion appears minimal. This study found no significant differences between the solutions and the placebo. Thus, it can be concluded that consuming a dextrose-based solution before exercise did not offer any performance advantage over water. The additional substances included in solutions B, C, and D did not influence performance, carbohydrate metabolism, or fat metabolism during the exercise.

Indexed as

Athletic PerformanceBeveragesPhysical EnduranceSports Nutritional Physiological PhenomenaAdultArginineAthletesBlood GlucoseCross-Over StudiesDouble-Blind MethodFemaleHeart RateHumansLactic AcidMaleOxidation-ReductionArginineBlood GlucoseLactic Acidamino acidsbeetrootcarbohydrateEndurance performancesupplementations

Identifiers

PMID40468684
PMCPMC12138928

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.