SynthesisInflammatory bowel diseases2025
The Association of Inflammatory Bowel Disease and Eosinophilic Esophagitis: A Systematic Review and Meta-analysis.
Synthesis in Inflammatory bowel diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Inflammatory Bowel Disease and Eosinophilic Esophagitis.Gastroenterology & hepatology · 2026Article
- Prevalence of dysphagia and eosinophilic esophagitis in patients with inflammatory bowel disease or type 2 inflammation: a cross-sectional multicenter screening study.Therapeutic advances in gastroenterology · 2026Article
- Eosinophilic and mastocytic gastrointestinal diseases: current knowledge and controversy in histopathologic diagnosis.Translational gastroenterology and hepatology · 2026Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe association between inflammatory bowel disease (IBD) and eosinophilic esophagitis (EoE) remains unclear. We aimed to perform a systematic review and meta-analysis on the association between EoE, IBD, and other immune-mediated inflammatory diseases.
methodsA systematic literature search was conducted in Ovid MEDLINE, Ovid Embase, and the Cochrane Central Register of Controlled Trials (Ovid) from inception to July 2023. The primary outcome was to compare the frequency of an EoE diagnosis in IBD and other immune-mediated inflammatory disease processes versus control populations. Where pooled analysis was possible, we reported odds ratios (ORs) with 95% confidence intervals (CIs). I2 values were used to report heterogeneity, with values >50% suggesting substantial heterogeneity.
resultsWe identified 2612 eligible studies, of which 38 studies were included. A diagnosis of EoE was significantly greater in patients with IBD compared to the general population (OR 3.9; 95% CI, 2.6-5.9 [I2 = 99.5%]). There was no significant increase in EoE in patients with ulcerative colitis compared to Crohn's disease (OR 1.0; 95% CI, 0.7-1.3 [I2 = 88.7%]). EoE was also significantly increased in patients with atopic dermatitis (OR 2.4; 95% CI, 1.9-3.1 3 [I2 = 70.4%]) compared to those without atopic dermatitis.
conclusionsBoth IBD and atopic dermatitis were associated with an increased odds of EoE diagnosis. Further research is needed to determine the underlying mechanisms behind these potential associations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.