Oral administration of a liquid containing nitrous oxide abolishes vaso-occlusive pain in mice with sickle cell disease.
Ana Oddo, Fuad Abdulla, Annabelle Herold, Kathy Tang, Viacheslav Viatchenko-Karpinski, Iryna A Khasabova, Sergey G Khasabov, Mark Young, John D Belcher, Gregory M Vercellotti and 1 more
Article in Haematologica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
11 authors.
Ana OddoDepartment of Diagnostic and Biological Sciences, University of Minnesota.
Fuad AbdullaDivision of Hematology, Oncology and Transplantation, Department of Medicine and Vascular Biology Center, University of Minnesota.
Annabelle HeroldDepartment of Diagnostic and Biological Sciences, University of Minnesota.
Kathy TangDepartment of Diagnostic and Biological Sciences, University of Minnesota.
Viacheslav Viatchenko-KarpinskiDepartment of Diagnostic and Biological Sciences, University of Minnesota.
Iryna A KhasabovaDepartment of Diagnostic and Biological Sciences, University of Minnesota.
Sergey G KhasabovDepartment of Diagnostic and Biological Sciences, University of Minnesota.
Mark YoungHillhurst Biopharmaceuticals, Inc., San Diego, CA.
John D BelcherDivision of Hematology, Oncology and Transplantation, Department of Medicine and Vascular Biology Center, University of Minnesota.
Gregory M VercellottiDivision of Hematology, Oncology and Transplantation, Department of Medicine and Vascular Biology Center, University of Minnesota.
Donald A SimoneDepartment of Diagnostic and Biological Sciences, University of Minnesota. simon003@umn.edu.
Funding
Treatment of cancer pain by lipid mediator Resolvin D1: role of Prostaglandin and Endocannabinoid signalingR01CA263777 · NCI · UNIVERSITY OF MINNESOTA · PI KHASABOV, SERGEY G · 2021 to 2025
$2.2M
Oral N2O Therapy in Treating Acute Vaso-Occlusive Pain in Sickle Cell DiseaseUG3NS127943 · NINDS · HILLHURST BIOPHARMACEUTICALS, INC. · PI BELCHER, JOHN D, GOMPERTS, EDWARD · 2022 to 2022
$2.1M
Neural Mechanisms of Cancer PainR01CA241627 · NCI · UNIVERSITY OF MINNESOTA · PI SIMONE, DONALD · 2019 to 2023
$1.9M
Oral N2O Therapy in Treating Acute Vaso-Occlusive Pain in Sickle Cell DiseaseUH3NS127943 · NINDS · HILLHURST BIOPHARMACEUTICALS, INC. · PI BELCHER, JOHN D, GOMPERTS, EDWARD · 2024 to 2024
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.
Oral administration of a liquid containing nitrous oxide abolishes vaso-occlusive pain in mice with sickle cell disease. · full record | Socratic