ReviewFrontiers in oncology2025
Application of bifidobacterium in tumor therapy.
Review in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Microbiome and Response to Therapy in Triple Negative Breast Cancer: A Systematic Review.Oncology research · 2026Pooled it
- The Dual Role of the Gut Microbiota in Cancer Chemoresistance.MicrobiologyOpen · 2026Review
- MMP1 Modulates Head and Neck Squamous Cell Carcinoma Progression and Therapeutic Response Via Tumour Microenvironment.International dental journal · 2026Article
- Bacterial-based cancer therapy: mechanisms and therapeutic advances.Molecular biomedicine · 2026Review
- Integrated Genomic, Structural, and Metabolomic Profiling of Freeze-Dried Postbiotic Supernatants Reveals Multi-Target Anticancer Activity Against Caco-2 Cells.Probiotics and antimicrobial proteins · 2026Article
- Insights into toxin-antitoxin systems in the genusApplied and environmental microbiology · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Current clinical cancer treatments primarily rely on surgery, chemotherapy, radiotherapy, and immunotherapy; however, each approach has inherent limitations. In recent years, nanomaterials have gained significant attention in oncology due to their advantages in precise drug delivery, enhanced targeting, and improved therapeutic efficacy. Nevertheless, their clinical application remains limited by challenges such as complex synthesis, high costs, low delivery efficiency, and poor biodegradability. Bifidobacterium (BBM), a clinically used probiotic, has demonstrated unique tumor-targeting potential due to its obligate anaerobic nature, allowing it to selectively colonize, proliferate, and expand within the hypoxic tumor microenvironment. Recent advancements in synthetic biology and bacterial engineering have enabled the modification of Bifidobacterium as a microrobot for molecular imaging, drug or gene delivery, and other therapeutic functions. Compared to nanomaterials, Bifidobacterium-based bacterial therapy holds promise in overcoming certain limitations while potentially enhancing comprehensive cancer treatment by modulating the tumor microenvironment and boosting host immune responses. This review summarizes the latest progress in Bifidobacterium-mediated tumor imaging and therapy, explores its mechanisms of action, engineering strategies, and clinical applications, and discusses future directions for optimizing its functional design to improve therapeutic efficacy and safety.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.