Evidence map›Paper›PMID 40469327›Full record

ArticleSurgical neurology international2025

Encephalitis-causing free-living amoebic infections in children: A rare and fatal disease.

John Vargas-Urbina, Raúl Martinez-Silva, Giuseppe Rojas-Panta, Gabriel Ponce-Manrique, Jerson Flores-Castillo, Dalila Y Martínez, Alfonso Martin Cabello-Vilchez, John A Cabrera-Enriquez

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In one paragraph

Article in Surgical neurology international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

John Vargas-UrbinaDepartment of Neurosurgery, Hospital Nacional Guillermo Almenara Irigoyen, La Victoria, Lima, Peru.
Raúl Martinez-SilvaDepartment of Neurosurgery, Hospital Nacional Guillermo Almenara Irigoyen, La Victoria, Lima, Peru.
Giuseppe Rojas-PantaDepartment of Neurosurgery, Hospital Nacional Guillermo Almenara Irigoyen, La Victoria, Lima, Peru.
Gabriel Ponce-ManriqueDepartment of Neurosurgery, Hospital Nacional Guillermo Almenara Irigoyen, La Victoria, Lima, Peru.
Jerson Flores-CastilloDepartment of Neurosurgery, Hospital Nacional Guillermo Almenara Irigoyen, La Victoria, Lima, Peru.
Dalila Y MartínezDepartment of Infectious, Tropical and Dermatological Diseases, Hospital Nacional Cayetano Heredia, Lima, Peru.
Alfonso Martin Cabello-VilchezAlexander Von Humboldt Institute of Tropical Medicine, Universidad Peruana Cayetano Heredia, Lima, Peru.
John A Cabrera-EnriquezService of Pediatric Infectious Diseases, Hospital Nacional Guillermo Almenara Irigoyen, La Victoria, Lima, Peru.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Brain infection by free-living amoebae can present as granulomatous amoebic encephalitis if caused by Cases Description: We present five cases with a diagnosis of brain infection by free-living amoebae treated at the Hospital Almenara. The patients received surgical treatment, and four of them also received antiparasitic treatment; in one case, the diagnosis was post-mortem. Antiparasitic treatment consisted of a combination of miltefosine, voriconazole, and albendazole mainly, with an average time of 4.8 months. All cases were diagnosed after the initial surgery, and two patients died. Diagnosis in all cases was by direct microscopy, but typing of the free-living amoeba involved was not possible. Conclusion: Brain infection by free-living amoebae is a disease with high morbimortality, which requires early diagnosis for a better prognosis if long-term combined treatment is established.

Indexed as

Amoebic encephalitisCentral nervous system protozoal infectionsFree-living amoebaMeningoencephalitisSubdural empyema (source: MeSH-BIREME)

Identifiers

PMID40469327
PMCPMC12134872

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.