ArticleFrontiers in public health2025
The relationship between intrinsic capacity and sarcopenia in middle-aged and older Chinese populations: the mediating influence of a novel nutritional index.
Article in Frontiers in public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- A novel nutritional index for hypertension risk and prediction: Cross-sectional, prospective, and trajectory evidence from the English Longitudinal Study of Ageing.The Journal of international medical research · 2026Article
- Leveraging interpretable machine learning to identify sarcopenia in middle-aged and older adults with intrinsic capacity decline: an analysis of CHARLS data under AWGS 2025.BMC medical informatics and decision making · 2026Article
- Association between intrinsic capacity and chronic lung disease among middle-aged and older adults: evidence from CHARLS and ELSA.BMC public health · 2026Article
- Association between a novel nutritional index and coronary heart disease in COPD patients: a retrospective study in China.BMC pulmonary medicine · 2026Article
- Lung function as a mediator: bridging appendicular skeletal muscle mass and dementia in middle-aged and older Chinese adults.European journal of medical research · 2026Article
- Comparison of novel nutritional index (TCBI) and insulin resistance index (TyG-BMI) for assessing cardiovascular disease risk: a cohort study.Journal of health, population, and nutrition · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Sarcopenia poses a major global health issue, with intrinsic capacity (IC) linked to its risk. This study examined the link between IC and sarcopenia in middle-aged and older Chinese individuals, focusing on the mediating role of triglycerides-total cholesterol-body weight index (TCBI), a new easy-to-calculate nutritional indicator. Methods: The investigation utilized 2015 data from the China Health and Retirement Longitudinal Study (CHARLS), focusing on individuals aged 45 years or older. Sarcopenia was evaluated using the 2019 guidelines from the Asian Sarcopenia Working Group. After adjusting for various confounders, we employed multiple logistic regression to explore the link between IC, TCBI, and sarcopenia, and used a mediation model to evaluate TCBI's role in the IC-sarcopenia. Subgroup analysis examined the heterogeneity among various groups. Results: This research encompassed a cohort of 6,554 individuals, displaying an average age of 59.4 ± 9.1 years, comprising 5,758 non-sarcopenia and 796 sarcopenia individuals. Mean IC was 5.1 ± 1.0 for non-sarcopenia group and 4.4 ± 1.2 for sarcopenia group. In the non-sarcopenia group, the median TCBI was 1446.4, and the interquartile range (IQR) was 922.3-2283.4. In the sarcopenia group, the median TCBI was 841.6, and the IQR was 584.9-1304.1. Significant differences in IC and TCBI were observed between the non-sarcopenia and sarcopenia groups ( Conclusion: The study found that IC is negatively correlated with sarcopenia, while TCBI is negatively correlated with sarcopenia, and TCBI mediates the relationship between IC and sarcopenia.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.