ReviewFrontiers in nutrition2025
Comprehensive systematic review and meta-analysis on the therapeutic efficacy of curcumin in osteoporosis: unveiling mechanisms and preclinical evidence.
Review in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Polyphenols regulate bone health through the gut-bone axis: molecular and applications in animal nutrition.Journal of animal science and biotechnology · 2026Review
- Therapeutic efficacy of mesenchymal stem cell-derived extracellular vesicles combined with injectable hydrogels in bone defect repair: a systematic review and meta-analysis of preclinical studies.Journal of biological engineering · 2026Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Osteoporosis (OP) is a common degenerative bone disease that seriously affects the quality of life of patients and poses a significant public health burden. Curcumin (CUR), a natural compound, has attracted much attention due to its anti-inflammatory, antioxidant and bone protective effects. However, there is currently a lack of systematic evaluation of the efficacy and mechanism of CUR in treating OP. Methods: This study is a systematic review and meta-analysis conducted per PRISMA guidelines. Studies meeting the inclusion criteria were retrieved and screened from the PubMed, Embase, Web of Science, and Cochrane Library databases. The included studies were limited to animal models of OP, and the intervention group was treated with a single dose of CUR. A meta-analysis was performed using Review Manager 5.4 and R Studio software. The standardized mean difference (SMD) and 95% confidence interval (CI) were calculated using the fixed-effect or random-effects model. Sources of heterogeneity, sensitivity, and publication bias were also explored. Results: A total of 17 high-quality studies involving 282 animals were included. The results of the metaanalysis showed that compared with the control group, CUR significantly increased bone mineral density (BMD of the femur: SMD = 2.18, 95% CI: 1.53-2.83; BMD of the tibia: SMD = 1.08, 95% CI: 0.30-1.87), improved the trabecular microstructure (BV/TV: SMD = 2.74, 95% CI: 1.84-3.64; Tb.N: SMD = 2.31, 95% CI: 1.65-2.96; Tb.Th: SMD = 2.09, 95% CI: 1.43-2.76; Tb.Sp: SMD = -2.32, 95% CI: -3.15 to -1.50). In addition, CUR significantly reduced serum CTX-1 and TRAP-5b levels, while increasing OCN and ALP levels. Mechanism studies have shown that CUR may act through OPG/RANKL, Wnt/β-catenin, NF-κB, MAPK, and TGF-β/Smad2/3 signaling pathways. Conclusion: This study is the first to systematically evaluate CUR's therapeutic effect on an OP animal model. The results show that CUR can significantly improve the pathological state of osteoporosis through a multi-target mechanism and has good therapeutic potential. However, heterogeneity and differences in the quality of the literature suggest that high-quality prospective studies are needed to verify the clinical value of CUR further.
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