ArticleFrontiers in nutrition2025
U-shaped relationship between frailty and non-HDL-cholesterol in the elderly: a cross-sectional study.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Article
- Frailty and Cardiovascular Risk.European cardiology · 2026Review
- Association between low-density lipoprotein cholesterol and frailty in adults aged ≥70 years: a cross-sectional study from Beijing, China.Frontiers in endocrinology · 2026Article
- Interactive effects of folate and methylmalonic acid on cardiovascular disease mortality: Epidemiological and experimental evidence.iScience · 2025Article
- Explainable machine learning-based prediction of early and mid-term postoperative complications in adolescent tibial fractures.Frontiers in surgery · 2025Article
- Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The modulation of lipid metabolism has been explored as a potential treatment for frailty, yet the association between non-high-density lipoprotein-cholesterol (non-HDL-C) and frailty remains unclear. Methods: This study utilized data from five cycles of the National Health and Nutrition Examination Survey (NHANES) and two cycles of the China Health and Retirement Longitudinal Study (CHARLS) to investigate this relationship. A 40-item frailty index scale, encompassing various dimensions of somatic functioning, psychological evaluation, and illness, was developed and individually evaluated for each participant. The variables underwent screening through Least Absolute Shrinkage and Selection Operator (LASSO) regression, univariate logistic regression, and Light Gradient Boosting Machine (LightGBM), with models developed through multivariate logistic regression and the LightGBM algorithm. Subsequently, subgroup analyses and interaction tests were conducted to substantiate correlations. Results: The U-shaped nonlinear association between non-HDL-C and frailty in older adults was validated using the LightGBM algorithm. Non-HDL cholesterol levels in the range of 117.54-194.64 mg/dL were less likely to be frailty, while the likelihood of developing frailty was higher at 47.99-63.87 or 274.01-259.65 mg/dL. Subgroup analyses and interaction tests confirm these results. Conclusion: It is plausible that an intricate nonlinear association between non-HDL-C and frailty in the elderly exists, though further rigorously designed studies are imperative to validate this relationship.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.